Epitope characterization

Clement, G., Boquet, D., Frobert, Y., Bernard, H., Negroni, L., Chatel, J.-M., Adel-Patient, K., Creminon, C., Wal, J.-M., and Grassi, J. 2002. Epitopic characterization of native bovine b-lactoglobulin. J Immunol Meth 266 67-78. 

Standardized reagents sifferentiating reagents specific diagnostic reagents panels used to profile epitopes in epidemio logical studies epitope characterization... 

Figure 6 from Carbohydrate Research, vol 311, Sakurai MH, Kiyohara H, Matsumoto T, TsumurayaY, Hashimoto Y, Yamada H (1998) Characterization of antigenic epitopes in anti-ulcer pectic polysaccharides from Bupleurum falcatum L. using several carbohy-drases. p 219-p229, all with permission from Elsevier... 

Xiang SH, Doka N, Choudhary RK, Sodroski J, Robinson JE. Characterization of CD4-induced epitopes on the HIV type 1 gpl20 envelope glycoprotein recognized by neutralizing human monoclonal antibodies. AIDS Res Hum Retroviruses 2002 18(16) 1207—1217. 

Lambert-Eaton syndrome is an antibody-mediated neuromuscular junction disorder. This disorder, which is most frequently encountered in patients with small-cell lung carcinoma, is characterized clinically by weakness and hyporeflexia. The impaired release of acetylcholine vesicles from presynaptic terminals at neuromuscular junctions that causes the weakness is a consequence of autoantibodies against small cell carcinoma epitopes that cross-react with and downregulate the expression of motor nerve terminal Ca2+ channels [39]. (See in Ch. 43.)... 

Cavani, A., et al., Characterization of epitopes recognized by hapten-specific CD-4+ T cells. Journal of Immunology, 154, 1232, 1995. 

Polyclonal antibodies Antibodies derived from a mixture of cells, hence containing various populations of antibodies with different amino add sequences. They are of limited use in that they will not all bind to the same epitopes following immunization with a haptenlcarrier protein conjugate. They are also difficult to purify and characterize, but have been used with success in the catELISA system. 

Our study underscores the significance of a quantitative interpretation of STD intensities using the CORCEMA-ST procedure for the characterization of binding epitopes at atomic resolution. In contrast to what was sometimes suggested [84], we show here that the STDs involving methyl resonances also give accurate information about epitopes in quantitative analyses. 

HV164 Astwood J.D., and R. D. Hill. Molecular characterization of Hor v 9. Conservation of a T-cell epitope among group IX pollen allergens and human VCAM and CD2. Adv Exp Med Biol 1996 409 269-277. 

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