Kukowska-Latallo

Kukowska-Latallo JF, Bielinska AU, Johnson J, Spindler R, Tomalia DA, Baker JRJ (1996) Proc Natl Acad Sci USA 93 4897... 

Eichman, J.D., Bielinska, A.U., Kukowska-Latallo, J.F., Donovan, B.W., and Baker Jr., J.R. (2001) Bioapplications of PAMAM dendrimers in dendrimers and other dendritic polymers. In Wiley Series in Polymer Science (M.J. Frechet, and D.A. Tomalia, eds.), pp. 441M61. John Wiley Sons, Ltd, West Sussex, UK. 

Kukowska-Latallo, J.F., Candido, K.A., Cao, Z., Nigavekar, S.S., Majoros, I.J., Thomas, T.P., Balogh, L.P., Khan, M.K., and Baker Jr., J.R. (2005) Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer Res. 65(12), 5317-5324. 

Kukowska-Latallo, J. F., Bielinska, A. U., Chen, C., Rymaszewski, M., Tomalia, D. A. and Baker J. R. Jr. Gene transfer using starburst dendrimers , in Kabanov, A. V., Feigner, P. L. and Seymour, L. W. (eds) Self-Assembling Complexes for Gene Delivery, John Wiley Sons, New York, 1998, pp. 241-253. 

Kukowska-Latallo JF, Chen C, Eichman J, Bielinska A, Baker JR (1999) Biochem Biophys Res Commun 264 253... 

Kukowska-Latallo IF, Raczka E, Quintana A, Chen C, Rymaszewski M, Baker Jr JR, Hum Gene Ther. 2m, 77,1385-1395. 

PAMAM) dendrimers groups at the dendrimer surface transfections Kukowska-Latallo etal., 1996)... 

Kukowska-Latallo, J.F., Bielinska, A.U., Johnson, J., Spindler, R., Tomalia, D.A. and Baker, Jr., J.R. (1996) Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers. I roc. Natl. Acad. Sci. USA, 93,4897-4902. 

This increase has two-fold implications. First, it implies that the fractured dendrimer is more flexible than the intact dendrimer and second, that the fractured dendrimer may expand due to an increase in positive charge at lower pH, a quantity that was described as essential for PEI mediated transfection. Indeed, when branched PEI was subjected to the same set of experiments, the same three-fold increase in viscosity was observed, lending support to the idea that PAMAM dendrimers act as proton sponges. Evidence of lysosomal buffering capability of PAMAM dendrimers was shown by Kukowska-Latallo et al. (1996) when they observed that the efficiency of G5-EDA dendrimers was enhanced by the addition of chloroquine, while the same molecule could not enhance transfection of G10-EDA dendrimers, which contain 40-fold more surface amine groups for proton absorption. 

Compared to viral vectors, the potential advantages of synthetic carriers (also called non-viral vectors) are apparent. Being synthetic, they could be made safe, non-immunogenic, easy to prepare and cost-effective. DNA delivered by these carriers may not be able to replicate or recombine into infectious forms. Among many reported non-viral carriers, including cationic polymers (Behr et al., 1989 Kukowska-Latallo et al., 1996 Wu and Wu, 1988) and cationic lipids (Feigner, 1990 Lee and Huang, 1997), the most frequently used form is cationic liposomes. 

Larsen RD, Rajan VP, Ruff MM, Kukowska-Latallo J, Cummings R, Lowe JB (1989) Proc Natl Acad Sci USA 86 8227... 

Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB (1990) Genes Dev 4 1288... 

Bielinska A, Kukowska-Latallo JF, Johnson J, Tomalia DA, Baker JR Jr (1996) Nucleic Acids Res 24 2176... 

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