Epigenetic factors

The epigenetics research tradition in human diseases has been rather weak thus far. Epigenetic factors have been investigated only when their role was evident from epidemological, cytogenetic, or other type of studies. The best example is the rare pediatric diseases that are often caused by... 

As mentioned above (Section 34.3.4.2) there is growing evidence supporting the hypothesis that schizophrenia is caused by a combination of genetic or epigenetic factors that affect limbic brain structures in the last trimester of development and stress-induced envkonmental influences during the final maturation of these structures late in human adolescence. This two hit idea has led to research directed at two potential targets for cytokine action the effects of cytokines on the... 

Shastry BS (2012) Genetic and epigenetic factors in disease and drug response. Biol Biomed Rep 2 217-222... 

Endocannabinoids might act as epigenetic factors, through the activation of cannabinoid receptors which emerge early in development. As to plant-derived cannabinoids, by mimicking the effects of natural ligands of cannabinoid receptors these would interfere with the sequence of events that results in the expression of several genes involved in brain development and, in this way, modify the maturation of several neurotransmitter systems (Ferndndez-Ruiz et al. 1992,1994,1996, 1999,2000). 

Studies, particularly with the [PS/+] prion, show that the frequency of spontaneous formation of a yeast prion is regulated by environmental, cellular and epigenetic factors [183, 184]. For example, for PSI1 ] to form de novo, there is... 

Berry, D. L. and Helmes, C. T., Role of epigenetic factors in dietary carcinogenesis, in Nutritional and Toxicological Aspects of Food Safety, Friedman, M., Ed., Plenum Press, New York, 1984, 91. 

Thiele GM, Tuma DJ, Willis MS, Vidali M, Stewart SF, Rolla R, Daly AK, Chen Y, Mottaran E, Jones DE, Leatherhart JB, Day CP, Albano E (2003) Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease. Hepatology, 37 410-419. 

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