Epidermal substitutes

N-4 position and a substituted ring at the N-l position. Because of this different chemical structure, cross-allergenicity with the other sulfonamides may not occur. However, because this has not been well studied, if a patient has a reaction to a sulfonamide antibiotic, whether or not he or she will have a reaction to these other sulfonamides remains controversial. Predisposition to allergic reactions is a more likely reason than cross-reactivity between these differing molecules.14 The sulfonamide antibiotics are significant because they account for the largest percentage of antibiotic-induced toxic epidermal necrolysis and Stevens-Johnson syndrome cases.15... 

Mutations of COL7A1 cause a skin disease called dystrophic epidermolysis bullosa. It is a blistering disease caused by the separation of the dermal-epidermal junction. Biochemical analysis revealed the single amino acid substitution in type Vll collagen that affects the supramolecular assembly of type VII... 

S-HODE-Substituted DAG Modulates Epidermal Signal Transduction... 

Fig. 2. Selective inhibition of diolein-activated epidermal protein kinase C (PKQ-p by 13S-hydroxyoc-tadecadienoic acid (13S-HODE)-substituted diacylglycerol (13S-HODE-DAC).

Cho, Y., and Ziboh, V.A. (1997) A Novel 15-Hydroxyeicosa-trienoic Acid Substituted Diacylglycerol (15-HETrE-DAG) Selectively Inhibits Epidermal Protein Kinase C- 3, Biochim. Biophys. Acta 1349,67-71. 

Fuller and co-workers employed a substitution reaction in their synthesis of a fluorescent photo-affinity probe, AX7593, for the detection of epidermal growth factor receptor (EGFR) signal toansduction processes associated with solid tumor formation. Reaction of 7-(benzyloxy)-4-chloro-6-methoxyquinazoline and 1,3-diaminobenzene in die presence of hot isopropanol generated the desired 4-quinazoline in 97% yield. Five additional steps (not shown) were required to access AX7593. 

Rana, V., Babita, K., Go3 1, D., Tiwaiy, A. (2005). Sodium citrate cross-linked chitosan films Optimization as substitute for human/rat/rabbit epidermal sheets, J. Pharm. Pharm. Set, 8,10-17. 

Richards CD, Hesketh TR (1975) Implications for theories of anaesthesia of antagonism between anaesthetic and non-anaesthetic steroids. Nature 256 179-182 Richter W, Messmer K, Hedin H, Ring J (1978) Adverse reactions to plasma substitutes incidence and pathogenesis. In Watkins J, Ward AM (eds) Adverse response to intravenous drugs. Academic Press, London, Grune Stratton, New York, pp 49-70 Rothman S, Orland FJ, Flesch P (1945) Group specificity of epidermal allergy to procaine in man. J Invest Dermatol 6 191-199... 

Besides temporary wound-dressing devices, BNC has been reported to have potential application as a human tissue substitute for use, for example, in cases where extensive loss of both the dermal and epidermal layers has taken place [51]. Despite the fact that microbial cellulose is not a biodegradable material in the short term, it could stay in the body forever without causing any toxic or inflammatory reactions [46]. 

Nogawa H, Takahashi Y (1991) Substitution for mesenchyme by basement-membrane-like substratum and epidermal growth factor in inducing branching morphogenesis of mouse salivary epithelium. Development 112 855-861. 

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