Epidermal growth factor structure/function

Dangles V, Femenia F, Laine V, Berthelemy M, Le Rhun D, Poupon MF, Levy D, Schwartz-Cornil 1. Two- and three-dimensional cell structures govern epidermal growth factor survival function in human bladder carcinoma cell Unes. Cancer Res 1997 57 3360-3364. 

R2. Ravenna, L., Lubrano, C., Di Silverio, F., Vacca, A., Felli, M. P., etal., Androgenic and antian-drogenic control on epidermal growth factor, epidermal growth factor receptor, and androgen receptor expression in human prostate cancer cell line LNCaP. Prostate 26, 290—298 (1995). R3. Rechler, M. M., and Nissley, S. P., Insulin-like growth factor (IGF)/somatomedin receptor subtypes structure, function and relationships to insulin receptors and IGF carrier proteins. Horm. Res. 24, 152-159 (1986). 

STRUCTURE AND FUNCTION OF THE EPIDERMAL GROWTH FACTOR (EGF/ErbB) FAMILY OF RECEPTORS... 

Freedman, S J, Sanford, D G, Bachovchin, W W, Furie, B C, Baleja, J D, Furie, B, Structure and function of the epidermal growth factor domain of P-selectin, Biochemistry, 35, 13733-13744, 1996. 

The term selectin was introduced to describe three adhesion molecules whose function and expression were highly selective and which possessed a terminal lectin domain. The nomenclature for each molecule relates to the cell on which they were first described E-selectin (endothelium), L-selectin (lymphocyte), and P-selectin (platelet). All three share similar structural features (1) an extracellular amino terminal carbohydrate-binding (i.e., lectin-like) domain that requires Ca2+ for activation (2) an epidermal growth factor-like domain and (3) repeated domains with homologies to complement-regulatoiy proteins. 

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