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Epidermal growth factor EGF

Whereas epidermal growth factor (EGF) enhances the radiosensitivity of human squamous ceU carcinoma cells in vitro (197), addition of EGF to hormone-deprived MCE-7 breast cancer cells prior to irradiation results ia iacreased radioresistance (198). An anti-EGE-receptor monoclonal antibody blocks the abiUty of EGE to enhance growth and radioresistance. Tumor cells, the growth of which is stimulated by EGE, appear to be protected those where growth is iohibited are sensitized (198). [Pg.496]

Figure 2.19 Organization of polypeptide chains into domains. Small protein molecules like the epidermal growth factor, EGF, comprise only one domain. Others, like the serine proteinase chymotrypsin, are arranged in two domains that are required to form a functional unit (see Chapter 11). Many of the proteins that are involved in blood coagulation and fibrinolysis, such as urokinase, factor IX, and plasminogen, have long polypeptide chains that comprise different combinations of domains homologous to EGF and serine proteinases and, in addition, calcium-binding domains and Kringle domains. Figure 2.19 Organization of polypeptide chains into domains. Small protein molecules like the epidermal growth factor, EGF, comprise only one domain. Others, like the serine proteinase chymotrypsin, are arranged in two domains that are required to form a functional unit (see Chapter 11). Many of the proteins that are involved in blood coagulation and fibrinolysis, such as urokinase, factor IX, and plasminogen, have long polypeptide chains that comprise different combinations of domains homologous to EGF and serine proteinases and, in addition, calcium-binding domains and Kringle domains.
Domains that are homologous to the epidermal growth factor, EGF, which is a small polypeptide chain of 53 amino acids. [Pg.29]

III. Tyr protein kinases A. Cytosolic tyrosine kinases src, fgr, abl, etc.) B. Receptor tyrosine kinases (RTKs) Plasma membrane receptors for hormones such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGE) Raf (a protein kinase)... [Pg.467]

The regulation of NHE2 is multifactorial. Chronic exposure to nitric oxide and gamma-interferon decrease NHE2 activity, whereas metabolic acidosis and chronic stimulation with epidermal growth factor (EGF) increase activity. [Pg.810]

Epidermal Growth Factor (EGF) Receptor Family Epidermal Growth Factor Receptor 2 (ErbB2) Epidural (Space)... [Pg.1491]

The antibody of human epidermal growth factor (EGF) was coupled to diol silica (prepared from silica and 3-glycidoxypropyltrimethoxysilane via an epoxy silica) by means of CDI. This supported antibody was utilized for immunoaffinity HPLC analysis of human epidermal growth factor. 213 ... [Pg.144]

EGF Epidermal growth factor (EGF)-like domain E(MFP) 0(0) 62(158) 1A3P... [Pg.196]

Epidermal growth factor (EGF), low-density lipoprotein (LDL), and transferrin (Tfn) are often used as model peptides because all three are taken up via clathrin-mediated endocytosis, but they are sorted into different pathways after endocytosis. [Pg.353]

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Epidermal

Epidermal growth factor

Heparin-binding epidermal growth factor HB-EGF)

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