Epidermal growth factor -derived

III. Tyr protein kinases A. Cytosolic tyrosine kinases src, fgr, abl, etc.) B. Receptor tyrosine kinases (RTKs) Plasma membrane receptors for hormones such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGE) Raf (a protein kinase)... 

In another study, CPMV particles that displayed a peptide derived from the epidermal growth factor receptor variant III (EGFRvIII) elicited specific antibody responses in mice against the peptide and protected mice from tumor challenge [45]. 

Epidermal growth factor and platelet-derived growth factor... 

Duchenne muscular dystrophy dimethyl formamide 5,5-dimethyl-1 -pyrroline-1 -oxide deoxynucleic acid diphenylene iodonium endothelium-derived relaxing factor epidermal growth factor early growth phase response gene ethyleneglycol- bis- (p- aminoethyl)-N,N,N, N -tetraacetic acid... 

Tyrosine kinase receptors are also involved in signaling by several growth fectors, including platelet-derived grovWh factor (PDGF) and epidermal growth factor (EGF). 

Kanter P, Leister KJ, Tomei LD, Wenner PA, Wenner CE (1984) Epidermal growth factor and tumor promoters prevent DNA fragmentation by different mechanisms. Biochem Biophys Res Commun 118 392-399 Kariya K-I, Kawahara Y, Tsuda T (1987) Possible involvement of protein kinase C in platelet-derived growth factor-stimulated DNA synthesis in vascular smooth musde cells. Atherosderosis 83 251-255... 

Epidermal growth factor (EGF) Platelet-derived growth factor (PDGF)... 

Yamada, K. et al. (2002). Role for brain derived neurotrophic factor in learning and memory. Life Sci. 70(7), 735-744. Yamada, M. et al. (1997). The neurotrophic action and signalling of epidermal growth factor. Progr. Neurobiol. 51(1), 19-37. 

Iressa (ZD 1839) is an orally active tyrosine kinase inhibitor selective for the epidermal growth factor (EGF) receptor tyrosine kinase. Iressa is undergoing clinical trials in the treatment of various solid tumors, including head and neck cancer, breast cancer and non-small cell lung cancer. Its antitumor activity is derived from the fact that the EGF receptor and EGF signaling are... 

A series of 6- and 7-aciylamide derivatives of 4-(phenylamino)-quinazoline and 4-(phenylainino)-pyridopyrimidine, classes of epidermal growth factor receptor (EGER) inhibitors, have been prepared from the corresponding amino compounds by reaction with actoyl chloride/base <99JMC1803>. Reaction of thionyl chloride with hexahydro-7-methyl-pyrimido[l,6-a]-pyrimidine-6,8-dione yields the corresponding 9,9 -thiobispyriiiudopyrimidine derivative <99JHC453>. 

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