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Epidermal growth factor cellular mechanisms

Tice DA, Biscardi JS, Nickles AL et al. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc Natl Acad Sci USA 1999 96 1415-1420. [Pg.122]

Trastuzumab (Herceptin) is a humanized monoclonal antibody against the HER2/neu (ErbB-2) member of the epidermal growth factor family of cellular receptors. The internal domain of the HER2/neu glycoprotein encodes a tyrosine kinase that activates downstream signals and enhances metastatic potential and inhibits apoptosis. HER2/neu is overexpressed in up to 30% of breast cancers and is associated with clinical resistance to cytotoxic and hormone therapy. A number of mechanisms of action have... [Pg.701]

Horton JK, Watson M, Stefanick DF, et al (2008) XRCCl and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell Res 18 48-63 Hutcheson IR, Knowlden JM, Jones HE, et al (2006) Inductive mechanisms limiting response to anti-epidermal growth factor receptor therapy. Endocr Relat Cancer 13(suppl 1) S89-S97... [Pg.249]

See other pages where Epidermal growth factor cellular mechanisms is mentioned: [Pg.166]    [Pg.308]    [Pg.705]    [Pg.397]    [Pg.220]    [Pg.259]    [Pg.240]    [Pg.194]    [Pg.92]    [Pg.3111]    [Pg.2389]    [Pg.159]    [Pg.210]    [Pg.550]    [Pg.237]    [Pg.256]    [Pg.216]    [Pg.342]    [Pg.50]    [Pg.43]    [Pg.809]    [Pg.62]    [Pg.685]    [Pg.620]   
See also in sourсe #XX -- [ Pg.163 ]



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Cellular growth

Cellular mechanism

Epidermal

Epidermal growth factor

Mechanical factors

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