Epidermal cell proliferation

As a result of pathogenic T-cell production and activation, psoriatic epidermal cells proliferate at a rate sevenfold faster than normal epidermal cells. Epidermal proliferation is also elevated in apparently normal skin of psoriatic patients. 

It is an autoimmune disease which is characterized by marked increase in undifferentiated epidermal cell proliferation and can increase the number of superficial cells having abnormal keratinization. 

Baker, B. S., Brent, L., Valdimarsson, H., Powles, A. V., Al-Imara, L., Walker, M., et al. (1992) Is epidermal cell proliferation in psoriatic skin grafts on nude mice driven by T-... 

Pullmann, H., K.J. Lennartz, and G.K. Steigleder, The effect of salicylic acid on epidermal cell proliferation kinetics in psoriasis. Autoradiographic in vitro-investigations (author s transl). Arch. Dermatol. Forsch, 1975,251 271-5. 

Paller, A.S., Siegel, J.N., Spalding, D.E., and Bremer, E.G., Absence of a stratum corneum antigen in disorders of epidermal cell proliferation detection with an anti-ganglioside GM3 antibody, J. Invest. Dermatol., 92, 240, 1989. 

Caldpotriene. Calcipotriene. (la.3j3.SZ7 .22 .245l-24-cyclopropyl-9.IO-secochola-.5.7.IO(l9).22-teuaene-l,3. 24-triul. calciputriol (Dovonex). is a. synthetic vitamin D< analogue indicated for topical application in the treatment of moderate plaque psoriasis. It has the same affinity for the vitamin D receptor as calcitriol. but its effect on calcium metabolism is 100 to 200 times less. Calcipotriene inhibits epidermal cell proliferation and enhances cell differentia-... 

As a result of pathogeiuc T-ceU production and activation, psoriatic epidermal cells proliferate at a rate sevenfold faster than normal epidermal cells. The germinative cell population increases in psoriatic skin, and duration of the epidermal cell cycle is calculated at 37.5 hours (versus 300 hours in normal skin). Lesion-free skin in psoriatic patients generally is considered to be involved because epidermal proliferation is elevated in apparently normal skin of psoriatic... 

Tuschil, A., Lam, C., Haslberger, A., and Lindley, I. (1992) Interleukin-8 stimulates calcium transients and promotes epidermal cell proliferation. J. Invest. Dermatol. 99, 294—298. 

PCL-PEG bFGF, EGF Nanofibers Wound heating promotion Enhanced epidermal cell proliferation Improved collagen and keratin synthesis Diabetic mouse Choi et al. (2011)... 

Oh HS, Smart RC (1996) An estrogen receptor pathway regulates the telogen-anagen hair folhcle transition and influences epidermal cell proliferation. Proc Natl Acad Sci USA 93(22) 12525-12530... 

E. Epidermal Cell Proliferation, Polyamines, Ornithine Decarboxylase... 

There are five reported cases of infants who have multiple defects " Unilateral ectromelia, and central nervous system anomalies and a skin disorder similar to that described above in patients with generalized skin involvement, limited to one side of the body. There is also a family history of psoriasis. The unique feature in these cases is that all abnormalities are unilateral (Figure 13.9). The kinetics of epidermal cell proliferation in the psoriasis-like skin are similar to... 

Decreased epidermal proliferation is considered to be the main mechanism of action of PUVA in the treatment of psoriasis. Once excited by UVA, psoralens can react with molecular oxygen, producing reactive oxygen species that cause mitochondrial dysfunction and lead to apoptosis of skin Langerhans cells, keratinocytes, and lymphocytes [134]. PUVA further decreases epidermal cell proliferation by noncompetitively binding to epidermal growth factor receptors and directly altering the cell surface membrane. 

GM-CSF) recruitment of inflammatory cells. Mediates epidermal cell proliferation and induces keratinocyte proliferation. ... 

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