Epidemiology estimates

R.W. Evans, J.W. Stamm, An epidemiologic estimate of the critical period during which human maxillary central incisors are most susceptible to fluorosis, J. Public Flealth Dent. 51 (1991)251-259. 

Relative risk is an epidemiological estimate of the fold increase in risk for a particular disease compared with the general population Relative risk also serves as a means of comparison among factors associated with a particular disease. Based on current data, the relative carcinogenic potential of the seven metals implicated as human lung carcinogens is as follows arsenic>chromium> nickel>beryIlium and cadmium>lead>cobalt. 

Relative risk is an epidemiological estimate of the fold increase in risk for a particular disease compared with the general population. 

The technique has continuity with historical epidemiological estimates of expected disease can be inferred from long-term determinations of asbestos exposures. 

The data on the epidemiology of anaphylaxis are widely varying estimates on the frequency of this condition. The findings are based on diverse study designs and are often not comparable. A clear conclusion from the data published so far is difficult. One major reason is that there is no universal consensus regarding the definition of anaphylaxis. The International Classification Codes (ICD) recording anaphylaxis are imprecise and do not properly reflect the epidemiological needs. 

The epidemiological evidence suggests that diet is a significant factor in the development of cancer. In their classic epidemiological study, Doll and Peto (1981) estimated that diet was responsible for as many as 35% of cancers in the West. An encyclopaedic report on nutrition and cancer by the World Cancer Research Fund (1997) has confirmed the central importance of diet as a major determinant of many forms of cancer across the globe. The interactions between diet and the biological processes leading to the... 

In most studies, phytoestrogen intake has been estimated by direct methods that evaluate food intake either by recall (food-frequency questionnaires -FFQs) or by record (food diary), and subsequently by composition databases based on information of this kind. Food-frequency questionnaires are widely administered to subjects involved in epidemiological studies. Their validity and reproducibility is considered sufficient when statistically correlated to data obtained from dietary records (a properly-completed and comprehensive food diary) and from analysis of blood and urine samples (Kirk et ah, 1999 Huang et al, 2000 Yamamoto et al, 2001 Verkasalo et al, 2001). FFQs can be repeated several times a year and may be administered to large populations. Such an approach provides an easy and low-cost method of assessing the... 

The prevalence of neuropathic pain is unknown because of the lack of epidemiologic studies. Current estimates suggest that approximately 1.5% of the population in the United States may be affected by neuropathic pain.7 However, this figure is probably an underestimate and will likely increase due to the increase in disorders associated with neuropathic pain in the ever-growing older population. Approximately 25% to 50% of all pain clinic visits are related to neuropathic pain.8 Central neuropathic pain is estimated to occur in 2% to 8% of all stroke patients.9... 

Bipolar disorders have been categorized into bipolar I disorder, bipolar II disorder, and bipolar disorder, not otherwise specified (NOS). Bipolar I disorder is characterized by one or more manic or mixed mood episodes. Bipolar II disorder is characterized by one or more major depressive episodes and at least one hypomanic episode. Hypomania is an abnormally and persistently elevated, expansive, or irritable mood, but not of sufficient severity to cause significant impairment in social or occupational function and does not require hospitalization. Most epidemiologic studies have looked at bipolar disorder of all types (bipolar I and bipolar II), or the bipolar spectrum, which includes all clinical conditions thought to be closely related to bipolar disorder. The lifetime prevalence of bipolar I disorder is estimated to be between 0.3% and 2.4%. The lifetime prevalence of bipolar II disorder ranges from 0.2% to 5%. When including the bipolar spectrum, the lifetime prevalence is between 3% and 6.5%.1... 

Dry eye is a frequent cause of eye irritation. A lack of a single diagnostic test for the condition limits the available epidemiologic data. One study estimated the prevalence of dry eye in the United States population age 65 and older at 14.6%, which is approximately 4.3 million Americans.29... 

Epidemiological and Human Dosimetry Studies. Epidemiological studies of radiation dose typically involve estimates of exposure that are based on whole-body measurements of internally-deposited americium. A need remains for epidemiological data that can provide quantitative human dose-response information while supplying additional information on the health effects of exposure to ionizing radiation and americium in particular, for cases of known internal exposure. 

There is a growing need to better characterize the health risk related to occupational and environmental exposure to pesticides. Risk characterization is a basic step in the assessment and management of the health risks related to chemicals (Tordoir and Maroni, 1994). Evaluation of exposure, which may be performed through environmental and biological monitoring, is a fundamental component of risk assessment. Biomarkers are useful tools that may be used in risk assessment to confirm exposure or to quantify it by estimating the internal dose. Besides their use in risk assessment, biomarkers also represent a fundamental tool to improve the effectiveness of medical and epidemiological surveillance. 

The health effect side of the diagram shows that unit risk estimates result from interactive analyses of health-affecting processes in the human body and observed effects in human populations (epidemiology). Health effects are identified by integrating clinical studies on humans or animals with studies of physical and chemical responses to pollutant agents in the human body. 

Exposures Of Children. Estimates are available for intake by children through ingestion of contaminated soils, dust, paint chips (EPA 1989c), and breast milk (Wolff 1983). However, some of these estimates are not current or well understood. To better understand the sensitivity of the nursing infant to chemicals such as lead, epidemiological studies, chemical monitoring, and model development and application are needed (Byczkowski et al. 1994). The bioavailability of lead from soil or dust on the hand after mouthing activity needs to be modeled. 

Human studies (including estimations of occupational and environmental exposure, epidemiological investigations, post-marketing surveillance for medicines, cosmetics and household and agricultural products, and the ethical and properly controlled use of human volunteers) [6]. 

Taking the possible health effects caused by inhaled Rn-222 progeny in the general public into account, better risk estimates based on epidemiological studies on the general population are urgently needed. 

In order to estimate the risk from environmental exposure it is necessary to utilize the underground miner epidemiology which relies exclusively upon data from occupationally exposed males. 

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