Enzymes in Synthesis

Unfortunately, frequent exposure to NSAIDS may also cause two detrimental effects. These agents inhibit the activity of cyclo-oxygenase, an important enzyme in synthesis of gastroprotec-tive prostaglandins. More importantly, NSAIDS may cause breaks... 

Andrew Regan was born in Rawtenstall, Lancashire and studied at the University of Cambridge, where he obtained his BA in 1981 (MA 1985), and his PhD in 1984, under the supervision of Professor Jim Staunton. From 1984-1985 he held an SERC-NATO Research Fellowship at Columbia University in the laboratories of Professor Gilbert Stork. He returned to the UK in 1985 to a lectureship in organic chemistry at the University of Kent at Canterbury, and since 1990 has been a lecturer in the Department of Chemistry at the University of Manchester. His research interests include the synthesis of phosphinic-acid hormone mimics, simplified macrolide antibiotics and anti-tumour compounds, stereoselective methodology, and the use of enzymes in synthesis. 

The use of a range of oxidative enzymes in synthesis is covered in Chapter 11, whilst the very powerful technique of regio- and stereo-specific biohydroxylation of even complex molecules by femienting whole-cell methods is covered in Chapter 12. 

Copper 80 mg 2-3 mg Metal storage/transport (ceruloplasmin) enzymes in synthesis of cartilage, bone, myelin interaction with iron Occurs in malnutrition, TPN anemia, neutropenia, skeletal and neurological defects Danger in Wilson s disease... 

Glycogen synthesis. The general pathway of glycogen synthesis is presented. The action of the key enzyme in synthesis, glycogen synthase, is shown by purple arrows. 

As already stated enzymes have great potential as catalysts for use in synthetic organic chemistry. The applications of enzymes in synthesis have so far been limited to relatively small number of large scale hydrol) ic processes used in industry and to a large number of small scale synthesis of products used in research. Following are given some of the applications of enzymes in hydrolytic processes. 

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