Gilbert Stork

Enamines 1 are useful intermediates in organic synthesis. Their use for the synthesis of a-substituted aldehydes or ketones 3 by reaction with an electrophilic reactant—e.g. an alkyl halide 2, an acyl halide or an acceptor-substituted alkene—is named after Gilbert Stork. 

Gilbert Stork (1921-1 was born on Mew Year s eve in Brussels, Belgium. He received his secondary education in France, his undergraduate degree atthe University of Florida, and his Ph.D. with Samuel McElvain atthe University of Wisconsin in 1945. Following s period on the faculty at Harvard University, he has been professor of chemistry at Columbia University since 1953. A world leader in the development of organic synthesis. Stork has devised many useful new synthetic procedures and has accomplished the laboratory synthesis of many complex molecules. 

Andrew Regan was born in Rawtenstall, Lancashire and studied at the University of Cambridge, where he obtained his BA in 1981 (MA 1985), and his PhD in 1984, under the supervision of Professor Jim Staunton. From 1984-1985 he held an SERC-NATO Research Fellowship at Columbia University in the laboratories of Professor Gilbert Stork. He returned to the UK in 1985 to a lectureship in organic chemistry at the University of Kent at Canterbury, and since 1990 has been a lecturer in the Department of Chemistry at the University of Manchester. His research interests include the synthesis of phosphinic-acid hormone mimics, simplified macrolide antibiotics and anti-tumour compounds, stereoselective methodology, and the use of enzymes in synthesis. 

Stork, G. Terrell, R. Szmuszkovicz, J. J. Am. Chem. Soc. 1954, 76, 2029. Gilbert J. Stork (1921-) was born in Brussels, Belgium. Being Jewish, he immigrated to the US due to rising antisemitism. He earned his Ph.D. at Wisconsin in 1945 and later became an assistant professor at Harvard. Since he was not awarded tenure in 1953, Stork moved to Columbia University where he has taught ever since. 

Department of Chemistry, Columbia University, New York, NY 10027. We greatly appreciate the guidance and support we received from Professor Gilbert Stork during the course of this work. 

This reaction, designed by Gilbert Stork, fosters monoalkylation. Enamines —[see Problem 17.5(a)(5)], of ketones are monoalkylated with reactive halides, such as benzyl and allyl, in good yield at the a C. The enamines are made from the ketone and preferably a 2° amine, RjNH. 

Submitted by Gilbert Stork,1 Paul A. Grieco,2 and Michael Greoson Checked by P. A. Aristoff and R. E. Ireland... 

The enamine alkylation procedure is sometimes called the Stork reaction, after its inventor, Gilbert Stork of Columbia University. The Stork reaction can alkylate or acylate the a position of a ketone, using a variety of reactive alkyl and acyl halides. Some halides that react well with enamines to give alkylated and acylated ketone derivatives are the following ... 

A simple example from the first report of this reaction by Gilbert Stork and his group in 1974 is the condensation of pentan-2-one with butanal to give the aldol and then the enone oct-4-en-3-one by acid-catalysed dehydration. The yields may seem disappointing, but this was the first time anyone had carried out a crossed aldol reaction like this with an unsymmetrical ketone and an enolizable aldehyde and got just one aldol product in any reasonable yield at all. 

Gilbert stark was bom in Brussels and became an assistant professor of chemistry at Harvard In 1948. Since 1953, Stork has been at Columbia University In New York. Sfnce the 1950s, he has pioneered new synthetic methods, among them many involving. enolates and enamines. 

Gilbert Stork (b. 1923 in Brussels, Belgium) is Eugene Higgins Professor of Chemistry, Emeritus, at Columbia University in New York. Following his secondary education in France, he got his B.S. degree from the University of Florida in 1942 and his Ph.D. from the University of Wisconsin in 1945. He spent some six years at Harvard University and has been at Columbia University since 1953. He is a Member of the National Academy of Sciences of the U.S.A. and a Foreign Member of the French Academy of Sciences and of the Royal Society (London). 

Today is the day of the annual Gilbert Stork Lecture at Columbia University. How did this lectureship come about ... 

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