Enzyme Susceptibility

1After72 hours hydrolysis 2Porcine pancreatic oamylase 3a-amylase from Bacillus species 4Amyloglucosidase from Aspergillus niger 

---

Induction of hepatic microsomal drug-metabolizing enzymes. Susceptible to inhibition of metabolism, primarily by CYP3A4. 

U) Incubation of enzyme-susceptible tissues with Vibrio ahoterae sialidase increased the number of binding sites proportional to the increase in GM1 ganglioside, as well as increased cellular sensitivity to the toxin (9.). 

Inhibitors which bind irreversibly to an enzyme often form a covalent bond to an amino acid residue at or near the active site, and permanently inactivate the enzyme. Susceptible amino acid residues include Ser and Cys residues which have reactive -OH and -SH groups, respectively. The compound diiso-propylphosphofluoridate (DIPF), a component of nerve gases, reacts with a... 

Radiation radiation, depending on wavelength and dose, has been shown to have a variety of effects, including increased gelatinization temperature, improved stability and reduced viscosity, swelling power and enzyme susceptibility. Radiation has also been used to promote chemical modification. Marquette et al.118 have a patent for microwaving starch to improve rheological stability and hot water dispersibility. They... 

If more than one species of fatty acid is present, its relative location on the glycerol may be important to its functionality, enzyme susceptibility, and oxidation stability of the fat/oil. Several conventions have been developed to specify arrangements of fatty acids on the glycerol molecule (if known). To avoid confusion from inversion of the 1 and 3 carbon positions, hierarchies have been established to designate the number 1 carbon under... 

The complexation of starch and thin-boiled starches with alkyl and aryl sulfonates gives a product that is readily soluble in warm water. This complexation also decreases the temperature of maximum swelling. Enzymic susceptibility is decreased and retrogradation is impeded.780... 

Ps. aeruginosa. When carbenicillin is substituted for cephaloridine, no such effect is observed as carbenicillin is itself an inhibitor of the inducible enzyme. All this evidence leads to the conclusion that the inducible j8-lactamase of Ps. aeruginosa plays a significant role in the resistance of the organism to enzyme-susceptible jS-lactam antibiotics. However, no lactamase-less mutants of Ps. aeruginosa have been isolated, so it is not possible to determine the exact role of the enzyme in resistance. 

Chlorcyclizine modified the midgut structure and increased the susceptibility of N. melanderi to parathion [72]. More recent biochemical studies have shown that M. rotundata possesses seven enzymes susceptible to organophosphate inhibition [73]. Since serine esterases are the major target of organophosphate insecticides, they were used to establish the... 

Heat and shear within the extruder barrel denature proteins thus many enzymes are inactivated. As a function of denaturation, protein solubility in water or dilute salt solutions is reduced, thereby changing protein functionality. SME may influence solubility more than does barrel temperature (Della Valle et aL, 1994). Wheat protein solubility decreases even at the relatively low temperatures (< 100°C) used for pasta extrusion (Um-madi et aL, 1995a). Large proteins may become dissociated into smaller subunits. Denaturation also exposes enzyme-susceptible sites, thus improving digestibility. 

Sullivan JW, Johnson JA (1964) Measurement of starch gelatirrization by enzyme susceptibility. Cereal Chem 41 73-77... 

While the reduced enzymic susceptibility of the aromatic ester bonds is caused by the interaction of the long chains in the polymer, the chain length itself has no direct influence on the biodegradability above a minimum molar mass. Tests with copolyesters from terephthalic acid, adipic acid and 1,4-butanediol which were chain extended with hexamethylene-diisocyanide resulted not in a decrease in the biological degradation rate (in a compost simulation test) although the molar mass of the pre-polyesters of about 48,000 g/mol was increased to 232,000 g/mol by the chain extension [14]. 

---