Envelope glycoprotein carbohydrate structure

The trisaccharide-hexapeptide partial structure (151) of aleukemia-virus envelope glycoprotein, which was obtained from 46 (see Section 11,2) via saccharide and carboxyl deprotection, has also been coupled to BSA to furnish a synthetic glycoprotein 152 containing 12% of carbohydrate in the form of the trisaccharide (19). 

Table 2. Carbohydrate substituents of viral envelope glycoproteins established by structure analysis.

T. Mizuochi, M. W. Spellman, M. Larkin, J. Solomon, L. J. Basa, T. Feizi, Carbohydrate structures of the human-immunodeficiency-virus (HIV) recombinant envelope glycoprotein gpl20 produced in Chinese-hamster ovary cells, Biochem. J., 1988, 254, 599-603. 

H. Geyer, C. Holschbach, G. Hunsmann, J. Schneider, Carbohydrates of human immunodeficiency virus. Structures of oligosaccharides linked to the envelope glycoprotein 120, J. Biol Chem., 1988,263, 11760 11767. 

HIV is a typical member of the retrovirus family, in that it is an enveloped virus that carries RNA as its genetic information. The structure of HIV (Fig. 2) has been determined by electron microscopy. The viral membrane is acquired from the infected cell as the virus buds through the cell membrane. Inserted into the viral membrane are protein molecules coupled to carbohydrates (glycoproteins) which are essential for viral infectivity and probably also play a role in the... 

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