Colitis Clostridium difficile

Buchner AM, Sonnenberg A Medical diagnoses and procedures associated with Clostridium difficile colitis. Am J Gastroenterology 2001 96 766-772. 

Hecht JR, Olinger EJ Clostridium difficile colitis secondary to intravenous vancomycin. Dig DisSci 1989 34 148-149. 

Suggested Alternatives for Differential Diagnosis Amebiasis, cholera, salmonellosis, schisto-mosis, yersiniosis, Clostridium difficile colitis, colon cancer, Crohn s disease, ulcerative colitis. 

The spectrum of gastrointestinal tract infections (GTI) cover a wide spectrum from asymptomatic Helicobacter pylori gastritis to self-limiting viral gastroenteritis to food poisoning to bacterial enterocolitis to antibiotic-associated Clostridium difficile colitis to typhoid fever with sepsis and multi-organ failure. 

Daptomycin has proven efficacy in a number of in vivo animal models, including soft tissue infections by MRSA, bacteraemia caused by S. aureus or vancomycin-resistant enterococci (VRE), Enterococcus faecalis pyelonephritis, MRSA osteomyelitis, MRSA and Bacillus anthracis pulmonary infections, Gram-positive endocarditis, Clostridium difficile colitis and S. pneumoniae and S. aureus meningitis.9,64 66... 

Gorbach SL, Chang TW, Goldin B. Successful treatment of relapsing Clostridium difficile colitis with Lactobacillus GG. Lancet 1987 2(8574) 1519. 

Cudmore MA, Silva J Jr, Fekety R, Liepman MK, Kim KH. Clostridium difficile colitis associated with cancer chemotherapy. Arch Intern Med 1982 142(2) 333-5. 

The mortality rate in patients with Clostridium difficile colitis is reported to be 1.6-3.2%,but these percentages can increase to 13.5% when we take into account all causes of death for patients with the diagnosis of Clostridium difficile colitis (Dallal et al. 2002). 

Observational studies Oral moxifloxacin (after initial intravenous cloxacillin, cefazo-lin or vancomycin) was studied in 48 patients with orthopedic implant infections due to sensitive Staphylococcus aureus ( = 33) or coagulase-negative staphylococci ( = 15) [40 ]. Overall cure rate was 83% and 71% if the implant was retained. Two subjects withdrew because of side-effects (4.2% 95% Cl = 0,9.5) with one case each of Clostridium difficile colitis and persistent dizziness. Eight relapses occurred, but in the six cases in which the organism was re-isolated resistance did not develop. 

Of 84 patients in the US Cubicin Outcomes Registry with cancer and neutropenia, five (6%) had adverse events that were possibly related to daptomycin (one each of Clostridium difficile colitis, rash, raised CK activity, diarrhea, and chroma-turia) [133 ], but none required withdrawal. 

Junpaparp P, Buppajarntham S, Madueno FV, Varadi G. Concomitant typhlitis and Clostridium difficile colitis developed after first R-CHOP chemotherapy in a non-Hodgkin lymphoma patient. BMJ Case Rep 2013 2013. 

A 58-year-old man with a medical history of schizoaffective disorder, delusional parasitosis and Clostridium difficile colitis (CDC) was hospitalised for worsening diarrhoea as a result of CDC exacerbation. He had been using oral silver colloidal solution purchased from internet for several months to purify his blood and kill the (delusional) parasites. Skin biopsy confirmed the diagnosis of argyria. 

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