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Engerix

The two hepatitis B vaccines available in the United States are Recombivax HB and Engerix-B. These vaccines are produced with recombinant DNA technology by inserting the gene for HBsAg into the plasmid that is synthesized by Saccharomyces cerevisiae cells. Both vaccines are effective in providing... [Pg.352]

Recombivax, Comvax, Engerix B, Tritanrix-HB, Infanrmix, Twinrix, Primavax, Hexavax All vaccine preparations containing rHBsAg as one component Vaccination 13... [Pg.111]

Engerix B (tradename) is a subunit vaccine containing purified recombinant hepatitis B surface antigen (HBsAg) that gained approval in the USA in 1998. It is indicated for active immunization against infection caused by all known serotypes of hepatitis B virus. [Pg.405]

The protective efficacy of Engerix B has been demonstrated in a number of trials, in the context of infants, children and adults. Seroprotection rates (measured as serum anti-hepatitis B antibody titres above a value of 10 mlU ml-1) of over 95 per cent were usually recorded. The product was found to be generally well tolerated. The most frequently reported adverse effects were local reactions at the injection sites, fever, headache and dizziness. Special consideration to risk benefit ratio should be given to MS patients, as exacerbations of this condition have been (rarely) reported following administration of hepatitis B and other vaccines. Engerix B is manufactured and marketed by GlaxoSmithKline. [Pg.405]

Special formulation indications For adult patients receiving hemodialysis and other immunocompromised adults, 1 dose of 40 /vg/ml (Recombivax HB ) or 2 doses of 20, ug/mL (Engerix-B ) administered simultaneously. [Pg.581]

Engerix-B Tetramune, Hib TITR Haemophilis b, diphtheria CRM 197 Hepatitis B 1989 SmithKlineBeecham Lederle-Praxis Biologies/American... [Pg.430]

Figure 2 Anti-HBsAg IgG titres ( SD) (Y-axis) in mice immunized with a single subcutaneous injection of small DRV liposomes composed of PC, DOPE, DOTAP, and DOGMann (molar ratios 4 2 1 1) containing pRc/CMV HBS DNA and the encoded antigen HBsAg ( ) or with HBsAg in the form of Engerix ( ). For other details, see the text. Abbreviations DRV, dehydration-rehydration vesicles PC, phosphatidylcholine DOPE, dioleoyl phosphatidylcholine DOTAP, 1,2-dioleyloxy-3-(trimethylamonium propane). Figure 2 Anti-HBsAg IgG titres ( SD) (Y-axis) in mice immunized with a single subcutaneous injection of small DRV liposomes composed of PC, DOPE, DOTAP, and DOGMann (molar ratios 4 2 1 1) containing pRc/CMV HBS DNA and the encoded antigen HBsAg ( ) or with HBsAg in the form of Engerix ( ). For other details, see the text. Abbreviations DRV, dehydration-rehydration vesicles PC, phosphatidylcholine DOPE, dioleoyl phosphatidylcholine DOTAP, 1,2-dioleyloxy-3-(trimethylamonium propane).
Hqjatitis B Vaccine (Engerix-B, Recombivax HB) Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine (Gardasil)... [Pg.51]

Vaccines made with recombinant proteins marshal an immune response to specific viruses to treat or prevent disease. Vaccines to prevent infection with the liver-damaging hepatitis viruses (Twinrix , Recombivax HB , and Engerix-B ) include a recombinant version of a hepatitis virus B protein. Recombinant hepatitis B protein is also included in some combination vaccines given to children. Comvax also includes a recombinant flu virus protein. [Pg.77]

Engerix B (rHBsAg produced in S. cerevisiae) SmithKline Beecham Vaccination against hepatitis B... [Pg.442]

The same name is also being used for some vaccines that differ in potency. As shown in Table 1.4, the two approved vaccines against hepatitis B, Recombivax HB and Engerix-B, both known as Hepatitis B Vaccine (Recombinant), when used as directed, are therapeutically equivalent in terms of their ability to induce antibodies that protect vaccinated individuals from hepatitis B virus infection. However, the dose and volume required to produce a satisfactory immune response are different for each product and for each age group. [Pg.10]

Hepatitis B Vaccine (Engerix-B, Recombivax HB) [Vaccine/ Inactivated] Uses Prevent Hep B Action Active immunization recombinant DNA Dose Adults. 3 EM doses 1 mL each 1st 2 doses 1 mo apart the 3rd 6 mo after the 1st Peds. 0.5 mL EM adult schedule Caution [C, +] 1 effect w/ immunosuppressives Contra Yeast allergy Disp Engerix-B Inj 20mcg/mL peds inj 10 mcg/0.5 mL Recombivax HB Inj 10 40 mcg/mL peds inj 5 mcg/0.5 mL SE Fever, inj site pain Interactions i Immune response W/ corticosteroids, immunosuppressants EMS None OD Unlikely... [Pg.183]

Cooper, C.L., Davis, H.L., Morris, M.L., Eller, S.M., Adhami, M.A., Krieg, A.M., Cameron, D.W., Heathcote, J. CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults A double blind phase I/II study. J Clin Immunol 24 (2004) 693-701. [Pg.300]

Saccharomyces Eukaryotic Improper posttranslation Engerix-B (HBV vaccine)... [Pg.24]

Engerix-B Hepatitis B vaccine GlaxoSmithKline 8/1989 Hepatitis B 5. cerevisiae CHO... [Pg.1423]

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Engerix-B

Hepatitis B vaccine (Engerix

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