Endless Possibilities

But we can play this game repeatedly, since there are endless possible properties that can arbitrarily be called o and . Unless there is a well-defined measure of specialness, by... 

When I was a child, I had three toys that provided endless possibilities a set of wooden blocks, a set of Tinkertoys, and an Erector Set. These three toys had a lot in common. Each had a nnmber of distinct strnctnral elements that could be assembled in an amazing nnmber of ways to create something new and different. This has a direct analogy to the concept of assembling molecnles from atoms the atoms are the strnctnral elements and they can be hooked together to make molecular constructs in a great many ways. 

Chapin RE, Stedman DB (2009) Endless possibilities stem cells and the vision for toxicology testing in the 21st century. Toxicol Sci 112 17-22... 

Dynamic combinatorial libraries (DCLs) are continuously interconverting libraries that evenmally evolve to an equilibrium distribution [61-65]. This approach has been used successfully in the discovery of stable supramolecular assemblies from mixtures. Due to the nearly endless possible peptide sequences that can potentially be synthesised, the DCL approach is attractive for the identification of supramolecular peptide interactions. Indeed, disulfide exchange between cysteine residues has been explored for this purpose [66, 67] as has peptide-metal binding [68]. We have recently demonstrated protease-catalysed amide exchange in this context, which allows for the evolution of the self-assembled peptide structures, and will therefore allow exploration of peptide sequence space for biomaterials design. 

Whether we will ultimately be able to create furniture from curved space, partake of a multidimensional reality, or directly view all of humanity s alternate histories, becomes less of a issue than being able to fuel the imagination with these endless possibilities. 

Examples of this philosophy can be found everywhere we look. People are determined to lose weight, quit smoking, run a marathon, or go back to school or any of hundreds of personal ambitions. They do this because they firmly believe they can. A philosophy like this can literally transform your life. It opens the doors to endless possibilities and virtually eliminates the concept of I can t. What a wonderful way to approach life ... 

The text should prove valuable to researchers and technologists in organic and biochemistry, especially in the new emerging fields of proteomics and nanotechnology. The future of these vibrant fields with endless possibilities is bright indeed. 

The discussion above demonstrates that in-line sample treatment in flow analysis presents endless possibilities. 

Finally we note the existence of repulsive exchange forces which arise when the electron clouds of the two molecules begin to overlap. These occur because of the exclusion principle which forbids two electrons to occupy the same orbital unless their spins are antiparallel. Since all orbitals are already occupied by electron pairs, any overlap means that some electrons must be transferred to anti-bonding orbitals of higher energy, which implies a repulsive interaction. This interaction, being of very short range, depends upon the exact relative positions of the two molecules and it is not worth while to consider the almost endless possibilities involved until we can deal with molecules fixed in a crystal lattice. 

The label-free voltammetry of DNA and proteins has been known for a long time bnt has recently started to blossom as an exciting field which new researchers are tempted to pursne with high motivation. With the endless possible combinations of amino acids in peptides and proteins, as well as the nucleobases in DNA and RNA, an immense variety of voltammetric signals can be obtained as a resnlt of aptamer-protein interactions. Since the method does not require any... 

Also, given the fact that synthetic polymers are created by chemical reactions, the possibilities of building different polymers are virtually endless, only restricted by chemical and thermodynamic laws and by the creativity of the synthetic polymer chemist. These endless possibilities have given rise to an enormous variety of synthetic polymers that find application in almost every conceivable field of human activity that deals with matter or physical objects. In addition, the enormous molecular stmctural versatility that is derived from the rich synthetic possibilities, translates into materials with extremely diverse properties, and therefore applications. 

The almost endless possibilities of mass spectrometry have been increased by yet another hopeful variant SELDI (surface-enhanced laser desorption ionization). SELDI combines protein chips with a UV-MALDl-TOF. The chips are solid aluminum strips coated with cationic or anionic ion exchangers, with hydrophile or hydrophobic molecules. Chips with activated surfaces are also available. These bind proteins covalently via their amino groups and enable you to coat chips with antibodies or receptors as you need them. Every chip has eight coated holes with a diameter of 1 mm. You apply the sample into the holes. Part of the pro-teins/peptides is adsorbed. The remainder is washed off. The adsorbed proteins/peptides are transferred into matrix and can then be analyzed in the mass spectrometer (Figure 7.8). What can SELDI do better than MALDI ... 

We cannot turn away from the inevitable future of medicine - with endless possibilities for health services and our patients, I don t think we would want to. 

The use of highly reactive carbanions in polymer synthesis has proven to be an interesting subject. The work which has been described here indicates some of the potential for novel polymeric materials. Examination of the polymers prepared in this work hints at some of the endless possibilities for the preparation of similar materials. There are many other dicarbanions which can be used in analogous syntheses. One molecule which would be interesting to examine is the dicarbanion of 2,3-dimethyl-1,3-butadiene which would result in a silicon containing polymer that contains a backbone diene unit. Another area of interest which has emerged from this work is the preparation of polymers which contain other inorganic atoms in the polymer backbone such as tin. We believe materials such as these would have some very unique properties. 

Matter is prone to endless fecundity, an inexhaustible vital force, and a beguiling power of temptation that enriches us to become creators on our own right... All matter flows out from endless possibilities, which run through it in sickly shudders... Anyone may knead and shape it [matter] it submits to all. All arrangements of matter are impermanent and loose, liable to retardation and dissolution. ... 

Plastics have played an important role in our history. After the invention of celluloid in the 1860s, plastics have demonstrated endless possibilities for application. Since then, plastics have become an integral part of our everyday life. 

This great versatility in bonding allows carbon to form a molecular framework with almost endless possibilities. Other elements-especially hydrogen, oxygen, nitrogen, sulfur, and chlorine-can incorporate into this framework to add even more variety. 

Figure 8.1 Some ol tlie (endless) possibilities to design 3,4-conncctcd nets. A Triangular linking ligands vviih metal ions wiili tetrahedral coordination. B Tetrahedral linking ligands with trigonal metal ions, C Partly preformed trigonal nodes enable nets that do not have alternating trigonal and tetrahedral nodes.

Almost endless possibilities exist for combining metal atoms, ligands, and ions. For the purpose of this chapter, we have selected only some of the more common complexes with at least some potential in initiating devices. 

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