Encapsulation encapsulating anticancer drugs

Kojima, C. Kono, K. Maruyama, K. Takagishi, T. Synthesis of polyamidoamine dendrimers having poly (ethylene Glycol) grafts and their ability to encapsulate anticancer drugs. Bioconjug. Chem. 2000, 11, 910-917. 

R. Saadati, S. Dadashzadeh, Z. Abbasian, H. Soleimanjahi, Accelerated blood clearance of PEGylated PLGA nanoparticles following repeated injections effects of polymer dose, PEG coating, and encapsulated anticancer drug, Pharm Res. 30 (4) (2013) 985-995. 

Use of dendrimers such as PAMAM, PPI and poly(ether hydro q lamine) (PEHAM) in drug deliveiy is mostly focused on cancer treatment. Dendrimers encapsulate anticancer drugs such as cisplatin and doxorubicin and agents for boron neutron capture therapy and photodynamic therapy. Cisplatin encapsulated dendrimers are reported to increase the bioavailability and selectivity of the drug on a solid tumor model which was provided by injection of B16F10 cells to C57 mice. ... 

Kato T, Nemoto R, Mori H, Takahashi M, Tamakawa Y, Harada M (1981) Arterial chemoembolization with micro-encapsulated anticancer drug. An approach to selective cancer chemotherapy with sustained effects. J Am Med Assocama 245 1123-1127... 

Hilder TA, Hill JM (2007) Modelling the encapsulation of the anticancer drug cisplatin into carbon nanotubes. Nanotechnology 18 Art. No. 275704. 

Brain delivery of the anticancer drug daunomycin provides an example of the in vivo application of OX26-inununoliposomes [111]. Different formulations of [ H]-daunomycin were i.v. administered to rats either as the free drug or encapsulated in conventional liposomes, sterically-stabilized liposomes, or PEG-conjugated immunohposomes (Table 2.3). Plasma samples were taken at defined time points and after 1 h the animal was killed and drug concentrations in brain tissue were determined. 

In addition to the hydrophobic interaction mentioned above to encapsulate guest molecules, other types of nonspecific interactions have also been explored to enhance binding. For example, block copolymer micelles based on PEO as hydrophilic segments and poly(/3-benzyl L-aspartate) as hydrophobic blocks have used to encapsulate doxombicin. The encapsulation efficiency of doxombicin, an aromatic anticancer drug molecule, has been found to be significantly higher. This observation has been attributed to the tt-tt interaction between the anthracycUne moiety of doxorubicin and the benzyl group of poly(/3-benzyl L-aspartate) (Cammas-Marion et al. 1999). 

The anticancer drugs delivered by liposomes include many small molecule drugs such as DOX, daunoru-bicin, platinates, taxanes, camptothecin, etc. The most successful development is DOX-encapsulated pegylated liposomes, with a trade name of Doxil in the U.S. market or Cylax in the European market. Doxil has shown significant clinical advantages over free DOX and conventional DOX liposomes.f Enhanced tumor accumulation of Doxil has been demonstrated in numerous preclinical studies over a variety of tumor models. Similar effects were also observed in clinical uses. 

Hofheinz RD, Gnad-Vogt SU, Beyer U, Hochhaus A (2005) Liposomal encapsulated anti-cancer drugs. Anticancer Drugs 16 691-707... 

ARSL types which have been found to have selective anticancer activity and substantial (for in vivo applications) stability, are currently being evaluated as carriers of anticancer drugs (encapsulated in their aqueous compartments and/or incorporated in their membrane) that may be delivered preferentially to cancer cells with the help of specific ligands. 

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