Electrospray ionization mass spectrometry identification

Gosetti, F. et ah. Oxidative degradation of food dye El33 Brilliant Blue FCF. Liquid chromatography-electrospray ionization mass spectrometry identification of the degradation pathway, J. Chromatogr. A, 1054, 379, 2004. 

Stintzing, F.C., Schieber, A., and Carle, R., Identification of betalains from yellow beet (Beta vulgaris L.) and cactus pear (Opuntia ficus-indica (L.) Mill.) by high-performance liquid chromatography-electrospray ionization mass spectrometry, J. Agric. Food Chem., 50, 2302, 2002. 

Vaidyanathan, S. Kell, D. B. Goodacre, R. Flow-injection electrospray ionization mass spectrometry of crude cell extracts for high-throughput bacterial identification. J. Am. Soc. Mass Spectrom. 2002,13,118-128. 

Janini, G.M., Chan, K.C., Conrads, T.P., Issaq, H.J., Veenstra, T.D. (2004). Two-dimensional liquid chromatography-capillary zone electrophoresis—sheathless electrospray ionization-mass spectrometry evaluation for peptide analysis and protein identification. Electrophoresis 25, 1973-1980. 

M. Puchalska, K. Polec Pawlak, I. Zadrozna, H. Hryszko and M. Jarosz, Identification of indigoid dyes in natural organic pigments used in historical art objects by high performance liquid chromatography coupled to electrospray ionization mass spectrometry, J. Mass Spectrom., 39, 1441 1449 (2004). 

Recently, a quantitative electrospray ionization/mass spectrometry method (ESI/MS) has been developed to analyze the molecular profile, or hpidome of different lipid classes in very small samples. In this method, total lipid extracts from tissues or cultured cells can be directly analyzed. By manipulating the ionization method, the mass spectrographs of polar or even non-polar lipids can be obtained [8]. This method and the use of lipid arrays allow precise and quantitative identification of the lipid profile of a given tissue, and map functional changes that occur. 

S. Hakkinen and S. Auriola, High-performance liquid chromatography with electrospray ionization mass spectrometry and diode array ultraviolet detection in the identification of flavonol aglycones and glycosides in berries. J. Chromatogr.A 829 (1998) 91-100. 

Ding J., Burkhart W., and Kassel D.B. (1994), Identification of phosphorylated peptides from complex mixtures using negative-ion orifice-potential stepping and capillary liquid chromatography/electrospray ionization mass spectrometry, Rapid Commun. Mass Spectrom. 8 94—98. 

Figeys, D., and Aebersold, R. (1998). Nanoflow solvent gradient delivery from a microfabricated device for protein identifications by electrospray ionization mass spectrometry. Anal. Chem. 70, 3721-3727. 

S. A. Base composition analysis of human mitochondrial DNA using electrospray ionization mass spectrometry a novel tool for the identification and differentiation of humans. Anal Biochem 2005, 344, 53-69. 

Alii, I., Kokoniewska, M., Gibbs, B. F., and Konishi, Y. (1998). Identification of peptides in Cheddar cheese by electrospray ionization mass spectrometry. Int. Dairy. 8, 643-649. 

Yoshitsugu, H., Fukuhara, T., Ishibashi, M., Nanbo, T., and Kagi, N. (1999). Key fragments for identification of positional isomer pair in glucuronides from the hydroxylated metabolites of RT-3003 (Vintoperol) by liquid chromatography/electrospray ionization mass spectrometry. J. Mass Spectrom. 34 1063-1068. 

Arnott, D. P Henzel, W. J. Stults, J. T. 1995. Identification of proteins from two-dimensional electrophoresis gels by peptide mass fingerprinting. In Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry, Snyder, A. E, ed., Washington, D.C. American Chemical Society, 619,226-243. 

Immler, D. Gremm, D. Kirsch, D. Spengler, B. Presek, R Meyer, H. E. 1998. Identification of phosphorylated proteins from thrombin-activated human platelets isolated by two-dimensional gel electrophoresis by electrospray ionization-tandem mass spectrometry (ESI-MS/MS) and liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). Electrophoresis, 19,1015-1023. 

Arraez-Roman, D., GomezCaravaca, A. M., Gomez-Romero, M., Segura-Carratero, A., and Fernandez-Gutierrez, A. (2006). Identification of phenolic compounds in rosemary honey using solid-phase extraction by capillary electrophoresis-electrospray ionization mass spectrometry. ]. Pharm. Biomed. Anal. 41,1648-1656. 

Toll, H. et al. Separation, detection, and identification of peptides by ion-pair reversed phase high performance liquid chromatography-electrospray ionization mass spectrometry at high and low pH. J. Chromatogr. A. 2005, 1079, 274—286. 

Ghassempour, A. et al. Monitoring of N-nitrosodiethanolamine in cosmetic products by ion-pair complex liquid chromatography and identification with negative ion electrospray ionization mass spectrometry. J. Chromatogr. A. 2008, 1185,43-48. 

In Table 5.1, a number of different conditions are presented for the separation and quantitation of anthocyanins. For simple profiles, the gradient profile is not critical as separations can be achieved relatively easy (Table 5.1 Methods 1-3). However, for samples such as blueberry and Concord grape, which contain complex mixtures with 15 or more anthocyanins or with several acylated anthocyanins, the gradient needed to get resolution can be more complex (Table 5.1 Method 4). Wine samples also fall into this category. Desorption nano-electrospray ionization mass spectrometry has been used to solve some of the resolution and identification issues (Table 5.1 Method 5). However, issues related to quantitation have not been dealt with in this method. 

Mol, R., Kragt, E., Jimidar, I., De Jong, G.J., Somsen, G.W. Micellar electrokinetic chromato-graphy-electrospray ionization mass spectrometry for the identification of drug impurities. J. Chromatogr. B 843, 283-288 (2006)... 

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