Human platelet activation

Tab. 12.2 Examples of NO donors shown to inhibit isolated human platelet activity in vitro.

Groenewegen WA, Heptinstall S. (1990). A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol. 

Fukunaga, K., Ishii, S., Asano, K., et al. (2001) Single nucleotide polymorphism of human platelet-activating factor receptor impairs G-protein activation. J. Biol. Chem. 276, 43025 3030. 

Parent, J. L., Le GouiU, C., Rola-Pleszczynski, M., and Stankova, J. (1996) Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production. Biochem. Biophys. Res. Commun. 219, 968-975. 

Chi EY, Weickmann J, Carpenter JF, Manning MC, Randolph TW. Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation. J Pharm Sci 2005 94(2) 256-274. 

Bodin S, Giuriato S, Ragab J, Humbel BM, Viala C, Vieu C, Chap H, Payrastre B. Production of phosphatidylinositol 3,4,5-trisphosphate and phosphatidic acid in platelet rafts evidence for a critical role of cholesterol-enriched domains in human platelet activation. Biochemistry 2001 40 15290-15299. 

Yanaga F, Poole A, Asselin J, Blake R, Schieven G, Clark EA, Law CL, Watson SP Syk interacts with tyrosine (diosphorylated proteins in human platelets activated by collagen and crosslinking of the Fcy-llA receptor. Biochem J 311 471-478,1995... 

Padoin E, Alexancfre A, Cavallini L, et al. Human platelet activation is inhiUted by he occupancy of glycoprotein Ilb/IIIa receptor. Arch Biocfaem Biophys 1996 333 497-413. 

Lanza F, BeRETZ A, STIERLE A, HaNAU D, KubiNA M, CaZBIAVE JP. Epinephrine potentates human platelet activation but is not an aggregating agent. 255 1276-1288,1988. 

Sl N VM, HtXMSEN H. Current aspects on human platelet activation and responses. EurJHaematol 38 383-399,1987. 

Malcolm KC, and Fitzpatrick FA (1992). Indirect actions fiiapsigargin in human platelets activation of eicosanoid biosynthesis and cellular signalling pathways. J. Pharm Exp. Thorap. 260 1244-1249. 

The effects of chitin and chitosan derivatives on in vitro human platelet activation were comparatively studied by Janvikul et al. (2006). Chitin, chitosan, partially A -acetylated chitosan (PNAC), A,0-carboxymethylchitosan (NOCC), Af-sulfated chitosan, and A-(2-hydroxy)propyl-3-trimeth-ylammonium chitosan chloride were tested for platelet aggregation assay. The results revealed that NOCC activated platelets most effectively. 

Stremler KE, Stafforini DM, Prescott S, et al. Human platelet-activating factor acety Ihydrolase. Oxidatively fragmented phospholipids as substrates. JBiol Chem 1991 266 110,95-11,103. 

Kirby, S., Norris, J., Bahnson, B., et al., 2012. An engineered mutant of human platelet activating factor acetylhydrolase hydrolyzes organophosphorus nerve agents. Communic. 11th International Meeting on Cholinesterases,... 

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