Electrochemical detection basic drugs

Jane, I., McKinnon, A., and Flanagan, R. J. (1985). High-performance liquid chromatographic analysis of basic drugs on silica columns using non-aqueous ionic eluents. II. Application of UV, fluorescence and electrochemical oxidation detection. J. Chromatogr. 323 191-225. 

On the other hand, detection difficulties are often experienced with basic drugs because their therapeutic levels are in the low ng ml" range. Some of the problems can be alleviated by employing either an electrochemical or fluorescence detector, since it is possible to achieve detection levels of sub-nanogram with these instruments, if operated under favourable conditions. Furthermore, both of these detection methods can enhance selectivity because analytes will only be detected if they contain an electrochemically active group or fluoresce. 

J.G. Besner, C. Band, J.J. Rondeau, L. Yamlahi, G. Caille, F. Varin and J. Stewart, Determination of opiates and other basic drugs by high-performance liquid chromatography with electrochemical detection, J. Pharm. Biomed. Anal, 1989, 7, 1811-1817. 

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