Tissue engineering elastin

Nettles DL, Chilkoti A, Setton LA (2010) Applications of elastin-like polypeptides in tissue engineering. Adv Drug Deliv Rev 62 1479-1485... 

Abstract Synthetic polymers and biopolymers are extensively used within the field of tissue engineering. Some common examples of these materials include polylactic acid, polyglycolic acid, collagen, elastin, and various forms of polysaccharides. In terms of application, these materials are primarily used in the construction of scaffolds that aid in the local delivery of cells and growth factors, and in many cases fulfill a mechanical role in supporting physiologic loads that would otherwise be supported by a healthy tissue. In this review we will examine the development of scaffolds derived from biopolymers and their use with various cell types in the context of tissue engineering the nucleus pulposus of the intervertebral disc. 

Chuang TH et al (2009) Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts. Tissue Eng Part A 15(10) 2837-2851... 

Daamen WF et al (2003) Preparation and evaluation of molecularly-defined collagen-elastin-glycosaminoglycan scaffolds for tissue engineering. Biomaterials 24(22) 4001-4009... 

In Nature, there are many examples of protein and peptide molecular self-assembly. Of the genetically engineered fibrous proteins, collagen, spider silks, and elastin have received attention due to their mechanical and biological properties which can be used for biomaterials and tissue engineering. 

Girotti et al. (2004) have designed and bio-produced elastin-like protein polymers (ELP) which contain biofunctional motifs with cell adhesion sequences required for tissue-engineering applications. The protein polymer contained periodically spaced fibronectin CS5 domains enclosing the cell attachment sequence REDV. The overall sequence,... 

Elastin is a major structural protein element found in many connective tissues that is known to impart resiliency and elasticity to mechanically loaded tissues. It is therefore no suiprise that the material has become an important tool in tissue engineering research [98]. Mature elastic fibers found in tissues contain structural subunits called tropoelastin, an amorphous 64 kDa monomer composed of 830 amino acids [14]. In the extiacellular space, the cell-synthesized tropoelastin is exposed to lysyl oxidase-mediated oxidation at available lysine residues and then... 

Li M et al (2006) Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds. J Biomed Mater Res A 79A(4) 963-973 Kenawy el R et al (2002) Release of leliacycline hydrochloride from electrospun poly (ethylene-co-vinylacetate), poly(lactic acid), and a blend. J Control Release 81(l-2) 57-64... 

Boland ED et al (2004) Electrospinning collagen and elastin preliminary vascular tissue engineering. Front Biosci 9 1422-1432... 

K. Ghofrani, et al.. Use of a collagen/elastin-membrane for the tissue engineering of dermis, Burns 25 (1999) 373-384. 

M. Keck, et al.. Adipose tissue engineering three different approaches to seed preadipocytes on a collagen-elastin matrix, Ann. Plast. Surg. 67 (2011) 484-488. 

E.D. Boland, J.A. Matthews, K.J. Pawlowski, D.G. Simpson, G.E. Wnek, G.L. Bowlin, Electrospinning collagen and elastin preUminary vascular tissue engineering. Front. Biosci. 9 (1422) (2004) C1432. 

D. G. Simpson, G.L. Bowlin, Suture-reinforced electrospun polydiox-anone-elastin small-diameter tubes for use in vascular tissue engineering a feasibility study, Acta Biomater. 4(1) (2008) 58-66. 

L. Nivison-Smith, J. Rnjak, A.S. Weiss, Synthetic human elastin microfibers stable cross-linked tropoelastin and cell interactive constructs for tissue engineering applications, Acta Biomater. 6 (2) (2010) 354-359. 

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