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Effects of hallucinogens

Martin WR, Sloan JW Relationship of CNS tryptaminergic processes and the action of LSD-like hallucinogens. Pharmacol Biochem Behav 24 393-399, 1986 McCall R Effects of hallucinogenic drugs on serotoninergic neuronal systems. Pharmacol Biochem Behav 24 359-363, 1986... [Pg.239]

Krebs-Thomson, K, Paulus, MP and Geyer, MA (1998) Effects of hallucinogens on locomotor and investigatory activity and patterns influence of 5-HT2A and 5-HT2C receptors. Neuropsychopharmacology 18 339-351. [Pg.208]

Heym, J. Rasmussen, K. and Jacobs, B.L. Some behavioral effects of hallucinogens are mediated by a postsynaptic serotonergic action ... [Pg.299]

Trulson, M.E. Heym. J. and Jacobs, B.L. Dissociations between the effects of hallucinogenic drugs on behavior and raphe unit activity in freely moving cats. Brain Res 215 275-293, 1981. [Pg.304]

Further evidence for serotonergic mediation of the effects of hallucinogens was provided by a report on the development of functional supersensitivity in the rat with a chronic denervation of spinal 5-HT neurons. Nygren et al. (138) reported that rats pretreated with intracistemally administered 5,6-dihydroxy-tryptamine (5,6-DHT), a 5-HT neurotoxin, subsequently showed greater hindlimb extensor facilitations to 5-MeODMT or L-tryptophan + nialamide at 1 week versus 1 day following pretreatment. [Pg.26]

Recent data utilizing a polysynaptic withdrawal reflex suggest that, in intact rats, a disinhibition hypothesis may be necessary to explain some of the facilitatory effects of hallucinogens. Low to moderate doses of the hallucinogen 5-MeODMT administered into the lateral ventricle facilitated (i.e., decreased the latency of) the tail flick response to radiant stimulation of the tail (22). Furthermore, either spinal transection alone or systemic administration of 5-HT antagonists in intact... [Pg.27]

The net effect of hallucinogens on spinal reflex behaviors will depend on a complex balance between the behaviorally excitatory ventral horn 5-HT re-... [Pg.28]

Receptor Systems that Might Mediate the Effects of Hallucinogens on Startle Model I inhibitory 5-HT receptors... [Pg.30]

Low doses of both indole and phenylethylamine hallucinogens potentiate the normal neophobia exhibited by rats placed into a novel environment, which typically results in an initial suppression of locomotion and investigation. These effects are extremely susceptible to the influences of ambient stimulation and handling. The action of hallucinogens on inhibitory 5-HT autoreceptors does not appear to be responsible for these effects. The relevance of either inhibitory or excitatory 5-HT receptors on target neurons to these effects of hallucinogens should be more thoroughly examined. [Pg.35]

SUMMARY THE ROLE OF INHIBITORY AND EXCITATORY 5-HT RECEPTORS IN MEDIATING THE EFFECTS OF HALLUCINOGENS ON UNCONDITIONED BEHAVIORS... [Pg.39]

In this chapter, we have attempted to answer two questions. First, what are the effects of hallucinogens on unconditioned behaviors As might be expected, they are complex and varied. Hallucinogens have generally excitatory effects on startle reflexes, spinal reflexes, and locomotor activity. They also produce or elicit unique behavioral syndromes in rats, cats, and monkeys that rarely occur in the npndrugged state. However, hallucinogens can also depress spinal... [Pg.39]

Tonge, S. R., and Leonard, B. E. (1972) Some observations on the behavioral effects of hallucinogenic drugs on rats Potentiation by two drugs affecting monoamine metabolism. Arch. Int. Pharmacodyn., 195 168-176. [Pg.44]

Commissaris, R. L., Lyness, W. H., Moore, K. E., and Rech, R. H. (1981) Central 5-hydroxy-tryptamine and the effects of hallucinogens and phenobarbital on operant responding in rats. Pharmacol Biochem. Behav., 14 595-601. [Pg.53]

As mentioned herein, other neurotransmitters are affected by hallucinogens. Accordingly, the opposite changes in 5-HT and DA neurotransmission produced by these drugs seem necessary but insufficient to evoke hallucinations. Current studies on the effects of hallucinogens on recently detected neuroactive com-... [Pg.88]

We now can examine the effects of hallucinogenic drugs at those sites where serotonin exerts excitatory actions. Roberts and Straughan (72) reported that the excitatory effects of iontophoretically applied serotonin on cortical neurons in acute decerebrate cats were effectively blocked by LSD in more than 60% of... [Pg.100]

Most studies to date have focused on monoamine systems therefore, it would be of interest to examine the effects of hallucinogenic drugs on the neurochemistry, specific receptor binding, and electrophysiology of other putative neurotransmitter and peptide systems, such as y-aminobutyric acid, glycine, acetylcholine, enkephalin, and substance P. [Pg.106]

Escape behavior, effects of LSD and other hallucinogens on, 79-80 Excitatory 5-HT receptors effects of hallucinogens on activity of, 55-56... [Pg.121]

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See also in sourсe #XX -- [ Pg.93 ]



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