Effect of fructose

Le, K. A. and Tappy, L. (2006). Metabolic effects of fructose. Curr. Opin. Clin. Nutr. Metab. 

To limit futile cycling between glycolysis and gluconeogenesis, the two pathways are under reciprocal allosteric control, mainly achieved by the opposite effects of fructose 2,6-bisphosphate on PFK-1 and FBPase-1. 

S. M. Lievonen, T. J. Laaksonen, and Y. H. Roos, Nonenzymatic browning in food models in the vicinity of the glass transition effects of fructose, glucose, and xylose as reducing sugar, J. Agric. Food Chem., 2002, 50, 7034-7041. 

Tappy, L., Randin, J.-R, Felbcr, J.-P, Chiolern, R., Simonson, D. C, Jcquicr, E, and EieFtonzo, R. A. (1986). Comparison of thermogenic effect of fructose and glucose in normal humans. Am. ]. Physiol 250, E718-E724. 

Ekdahl, E. N., and Ekman, P. (1984). The effect of fructose-2,6-bisphosphate and AMP on the activity of phosphorylated and unphosphorylated fructose-l,6-bisphosphatase from rat liver. FEES Lett. 167, 203-209. 

Ehringer W, Su S, Chiang B, Stillwell W, Chien S (2002) The membrane destabilizing effects of fructose-1, 6-diphosphate on membrane bilayers. Lipids 37 885-892... 

F15. Frohman, C. E., and Orten, J. M., Tracer studies of acids of the tricarboxylic acid cycle II. Effect of fructose and bicarbonate on acetate metabolism in liver of diabetic rats. J. Biol. Chem. 220, 315 (1956). 

Boiteux, A. S.C. Muller. 1983. The effect of fructose 2,6-bisphosphate on the regulation of glycolytic flux in yeast extract. Abstract S-04/TH-045.15th FEBS Meeting, Brussels, Belgiiun. 

Espinet, C., Bartrons, R. Carreras, J. (1988). Effects of fructose 2,6-bisphosphate and glucose 1,6-bisphosphate on phos-phofructokinase from chicken erythrocytes. Comp. Biochem. Physiol, 90B, 453-7. 

Kalichevsky M.T., Blanshard J.M.V., The effect of fructose and water on the glass transition of amylopectin, Carbohydr. 

Untreated, oleander seed poisoning carries a mortality of 10% in Sri Lanka and treatment of yellow oleander poisoning is limited to the use of repeated doses of activated charcoal and atropine [17 antidigoxin antibodies are not available for routine use because of the high cost. Based on an animal study and on a small phase II study in patients with yellow oleander poisoning, a double-blind, randomized, placebo-controlled trial has been set up to assess the effectiveness of fructose-l,6-diphosphate (FDP) in acute yellow oleander poisoning [18 ]. Eligible patients will be randomized to either FDP or an equal amount of isotonic saline. The primary outcome measure will be sustained reversion to sinus rhythm at a rate of over 50/minute within 2 hours. Secondary outcomes will include death, reversal of hyperkalaemia at 6, 12, 18, and 24 hours, and maintenance of sinus rhythm. 

Effect of fructose, dihydroxyacetone, glycerol, and glucose on metabolites and related compounds in liver and kidney,... 

EFFECTS OF FRUCTOSE ON PURINE NUCLEOTIDE METABOLISM IN ISOLATED RAT HEPATOCYTES... 

In recent years it became apparent that fructose metabolism in the liver tissue has considerable effects on purine nucleotide metabolism. There is ample evidence that fructose metabolism is associated with acceleration of nucleotide degradation (1-5) and evidence is accumulating (6-8), indicating an acceleration effect of fructose also on purine synthesis. 

The present investigation was undertaken in an attempt to further clarify the effects of fructose on purine nucleotide metabolism. Isolated rat hepatocytes were chosen as a model system, since they allow the study of each pathway of purine metabolism separately and without interference from other tissues. 

Fig, 1. - Effect of fructose on isolated rat hepatocyte.s content of ATP, PP-rib-P and Pi, on the rate of de novo purine synthesis (( C) formate incorporation) and on PP-rib-P availability for metabolic reaction (( C) adenine incorporation). The time of incubation indicates the time of incubation with 28mM glucose or fructose before the assay of the specified parameter. The measurement of the rate of incorporation of ( C) formate and of ( C) adenine required additional incubation of 30 min, following the incubation period indicated in the figure. Thus, for these two measurements, 0 time of incubation values refer to values obtained during the 30 min assay incubation period alone (without preincubation). 0 - incubation with glucose o - incubation with fructose. 

Fig. 1. Effect of fructose on serum urate. (Modified from Fox and Kelley, 1972).

Fig. 5. Effect of fructose infusion on concentration of PP-ribose-P, ribose-5-phosphate, and ATP in erythrocytes. Results are expressed as per cent of control values. Control values represent mean S.D. (vertical bars) of three different samples obtained during a 60 min. period immediately preceeding infusion of fructose. Open squares, patient J.W. closed squares, patient L.L. open circles, patient H.M. and closed circles, patient A.B. (From Fox and Kelley, 1972).

Lotito SB, Frei B. The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids. Free Radio Biology Med. 2004 37(2) 251-258. 

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