Dynamic combinatorial chemistry thermodynamic control

Keywords Dynamic combinatorial library Constitutional dynamic chemistry Reversible reactions Supramolecular chemistry Thermodynamic control... 

Dynamic combinatorial chemistry (DCC) has proven extremely useful in creating complex mixtures of interchanging compounds termed dynamic combinatorial libraries (DCL). Key to the formation of such DCLs is a reversible chemical process that allows the library members to interconvert. The formation of imines from aldehydes and amines is a prominent example for the creation of a DCL. Since the overall distribution of compounds is under thermodynamic control, external stimuli can be used to bias the DCL toward a specific member of the library. This approach has been exploited successfully in the search of potent receptors for molecules of pharmacological interest, the creation of supramolecular assemblies, and ligands for biomacromolecules. ... 

Dynamic combinatorial chemistry, as a method for the generation of new molecules by means of reversible reactions between simple building blocks under thermodynamic control. In a dynamic combinatorial library (DCL), all constituents are in equihbrium, and their distribution is determined by their... 

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