Constitutional dynamic chemistry

Scheme 2 Constitutionally dynamic chemistry for the lanthanide-copper-glycinato coordination polymers, showing metalloligands a-f...

Other terms have been employed for this general concept, including self-assembled combinatorial libraries, constitutional dynamic chemistry, and virtual combinatorial libraries . Dynamic combinatorial chemistry and dynamic combinatorial library seem to have found the broadest usage, while virtual combinatorial library is perhaps best reserved for conditions under which library members form at concentrations below detection limits in the absence of target (e.g.. Reference 81). 

Lehn, J.-M. From supramolecular chemistry towards constitutional dynamic chemistry and adaptive chemistry. Chem. Soc. Rev. 2007, 36, 151-160. 

Giuseppone, N. Fuks, G. Lehn, J.-M.Tunable fluorene-based dynamers through constitutional dynamic chemistry. Chem. Eur. J. 2006, 12, 1723-1735. 

J.-M. Lehn, Lecture presented at the University of Bologna on December 4, 2006 From supramolecular chemistry to constitutional dynamic chemistry J.-M. 

Constitutional Dynamic Chemistry Bridge from Supramolecular Chemistry to Adaptive Chemistry... 

From Supramolecular Chemistry to Constitutional Dynamic Chemistry. 5... 

Supramolecular chemistry has experienced an extraordinary development in the last forty years or so, at the triple meeting point of chemistry with biology and physics. It has given rise to numerous review articles, special issues of journals and books [1-6]. The intention here is to provide a view emphasizing its development towards constitutional dynamic chemistry, together with some conceptual considerations and an outlook, along and beyond the lines earlier horizons, towards... 

Fig. 3 Constitutional dynamic chemistry at both the supramolecular (left) and the molecular (right) levels...

CA Carbonic anhydrases CDC Constitutional dynamic chemistry DCC Dynamic combinatorial chemistry DCL Dynamic combinatorial library(ies)... 

Fig. i Constitutional dynamic chemistry applied to bovine carbonic anhydrase bCA II isozyme and elaboration of constitutional dynamic library (CDL). Precursor amines a-d and aldehydes 1-3 and resulting components of the combinatorial library Ia-c-3a-c. HPLC traces of the final reaction mixtures showing amplification of 3c and 3d (adapted from [49])... 

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