Dulcolax - Bisacodyl

It should be noted that routine crushing of tablets should not be recommended. The bioavailability of marketed tablets should be satisfactory. Moreover, crushing of some tablets (e.g. Dulcolax [bisacodyl]) can cause severe side effects, while crushing of tablets intended for controlled or sustained release can cause dose dumping and dangerously high blood concentrations of drug. 

Bisa.codyl, 4,4 -(2-PyridyLmethylene)bisphenol diacetate [603-50-9] (Dulcolax) (9) is a white to off-white crystalline powder ia which particles of 50 p.m dia predominate. It is very soluble ia water, freely soluble ia chloroform and alcohol, soluble ia methanol and ben2ene, and slightly soluble ia diethyl ether. Bisacodyl may be prepared from 2-pyridine-carboxaldehyde by condensation with phenol and the aid of a dehydrant such as sulfuric acid. The resulting 4,4 -(pyridyLmethylene)diphenol is esterified by treatment with acetic anhydride and anhydrous sodium acetate. Crystallisation is from ethanol. 

Bisacodyl (Dulcolax)—Do not chew tiie tablets or take them within 1 hour of taking antacids or milk. 

Bisacodyl (Dulcolax, 5-10 mg orally (tabs) or rectally Second-line agent after bulk laxatives... 

Bethanechol (U recholine) Biperiden (Akineton) Bisacodyl (Dulcolax)... 

Bisacodyl (Dulcolax) causes colonic contraction and inhibits water absorption in the small and large intestine. 

Long-term use of stimulant laxatives bisacodyl (Dulcolax), cascara sagrada, and Neoloid except in the presence of opiate analgesic use May exacerbate bowel dysfunction. High... 

Oral 12 mg capsules Bisacodyl (generic, Dulcolax, others)... 

Stimulant laxatives Bisacodyl, 5-15 mg daily. Senna, dosage varies, consult product labeling Correctol, Dulcolax, Ex-Lax, Senokot, various generic Stimulant laxative actions include direct irritation of intestinal mucosa or stimulation of the myenteric plexus, resulting in peristalsis. These agents may also cause alteration of fluid and electrolyte absorption, resulting in luminal fluid accumulation and bowel evacuation. 

Bisacodyl (Dulcolax) [OTC] [Stimulant Laxative] Uses Consti-pation preop bowel prep Action Stimulates peristalsis Dose Adults. 5-15 mg PO or 10 mg PR PRN Peds. <2y 5 mg PR PRN >2 y 5 mg PO or 10 mg PR PRN (do not chew tabs or give w/in 1 h of antacids or milk) Caution [B, ] Contra Acute abd or bowel obst, appendicitis, gastroenteritis Disp Tabs, supp, enema soln... 

Nalidixic acid (l-ethyl-7-methyl-l.8-naphtlmdine-4-one-3-carboxylic add), many tradenames (e.g.. Nalidicron ), is an antibacterial. Bisacodyl [4,4 -(2-pyridylmethylene)diphenol diacetate], tradename Dulcolax, is a laxative. 

Manufacturer Dulcolax - Boehringer-Ingelheim Consumer Healthcare, Bisacodyl - Generic... 

Opioid-induced constipation is more troublesome in older patients, and it should be anticipated by instituting laxative therapy along with the narcotic. A typical laxative regimen consists of psyllium and a stool softener. A mild stimulant laxative such as bisacodyl (Dulcolax) can be added if constipation becomes problematic. 

Example Bisacodyl (Dulcolax) Route PO/Rectal Pregnancy category C Pharmacokinetic Minimal absorption following PO, rectal administration. Absorbed drug excreted in urine remainder eliminated in feces. 

Bisacodyl is a laxative that is indicated in short-term treatment of constipation evacuation of colon for rectal and bowel evaluation preparation for delivery or surgery. Bisacodyl is the only diphenyhnethane derivative available in the United States. It is marketed as an enteric-coated preparation (Dulcolax, Correctol, others) and as a suppository for rectal administration. The usual oral daily dose of bisacodyl is 10 to 15 mg for adults and 5 to 10 mg for children 6 to 12 years old. The drug requires hydrolysis by endogenous esterases in the bowel for activation, and so the laxative effects after an oral dose usually are not produced in less than 6 hours taken at bedtime, it will produce its effect the next morning. Suppositories work much more rapidly. 

Bisacodyl is the only diphenylmethane derivative available in the U.S. It is marketed as an enteric-coated preparation (dulcolax, coRREcroL, others) arul as a suppository for rectal administration. The usual oral daily dose of bisacodyl is 10-15 mg for adults and 5-10 mg for children 6-12 years old. 

Bisacodyl (e.g., Dulcolax) Increases water and electrolytes in feces and increases intestinal motility. Continuous use may cause severe diarrhea. PO. Softens feces in 6-8 hrs. 

Ex-Lax, Feen-A-Mint, Correctol), bisacodyl (Dulcolax), cascara sagrada, senna (Senokot), and castor oil (purgative). Bisacodyl and phenolphthalein are two of the most frequently used and abused laxatives because they can be purchased over-the-counter. 

The elderly male client diagnosed with diverticulosis tells the nurse he takes bisacodyl (Dulcolax), a stimulant laxative, daily. Which teaching would be most important for the nurse to provide the client ... 

Trade names Bisacodyl, Dulcolax, Evac-O-Kwik, Fleet Bisacodyl Enema... 

Krishnaram AS, Bharathi S, Krishnan S. An interesting case of bisacodyl (dulcolax)-induced chromhidrosis. Indian J Dermatol Venereol Lep-rol 2012 78 756-8. 

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