DryLab operation

With the completion of data entry, a Laboratory screen can be displayed (Fig. lb). Several display options are shown at the top of the screen map, table, results 

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Other chromatographic systems snch as DryLab 2000 Pins from LC Resonrces (http //www.lcresources.com) incorporate aspects of method development and validation throngh simnlation software combined with actnal experiments to determine optimal operating conditions. This system is designed to generate efficient method development and method optimization experiments. Resnlts from these experiments can be nsed for the evaluation of robusmess as part of the validation for methods developed using this type of software. 

Since the HPLC method for CU must be fast, use of DryLab or other commercially available software is recommended to develop a short run-time method. An example chromatogram in Figure 15-19 illustrates a fast LC run for a combination drug product containing three APIs. In addition, the use of HPLCs that can operate at higher pressures (up to 9000-15,000psi) could also be used. More details on fast HPLC can be found in Chapter 17. 

Software for computer-facilitated H PLC method development has been commercially available for the past two decades. The present chapter describes one such computer program DryLab (Rheodyne LLC, Rohnert Park, CA, USA). The detailed operation of this software is presented here, with a half dozen examples of its real-world application. The present version of DryLab is the result of two decades of continuing development and use by practicing chromatographers. 

ChromSword Auto is presently being marketed as the most effective and mature system. As mentioned above, none of the systems, however, can accomplish a development with optimization in a completely unsupervised manner. Nevertheless, the goals can be achieved with all of them. Crucial for the purchase, however, is what software is already used for controlling HPLC devices in the laboratory, whether DryLab has already been installed, whether apparatus of a certain manufacturer is already in operation, or whether management prescribes a certain manufacturer. One must also decide whether one trusts only the security and... 

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