Drug-resin complex

Drug-resin complex particles Resin - SO3 Dru Resin [N(CH3)3 ]Dru ... 

Cuna, M., Alonso, M. J., and Torres, D. Preparation and in vivo evaluation of mucoadhesive microparticles containing amoxycillin-resin complexes for drug delivery to the gastric mucosa. Eur. J. Pharm. Biopharm. 51(3) 199-205, 2001. 

Note. Tussionex —is an ion-exchange resin complex with it, that essentially releases the drug gradually in a sustained rate and is said to produce effective cough-suppression over a span of 10-12 hours. 

Irwin, W. J., MacHale, R. and Watts, P. J., Drug-delivery by ion-exchange. Part VII Release of acidic drugs from anionic exchange resinate complexes. Drug Dev. Ind. Pharm., 16, 883-898 (1990). 

The drug may be incorporated in a slowly eroding matrix of waxy materials, embedded in a plastic matrix, complexed with anion exchange resins or incorporated in a water-insoluble hydrophilic matrix. Drug release from these systems occurs by several mechanisms diffusion, dissolution, ionic exchange or osmotic pressure [1,2], depending on the type of polymeric excipient present and the formulation used. 

A number of plants of the cucumber family yield these drastic drugs. They are of complex composition, each containing several active principles, resinous and alkaloidal. They produce continuous watery stools, with intense irritation and hyperemia (Sollmann, 1944). 

Complexes can also be formed with compounds that act as ion-exchange resins. The cholesterol-lowering drug cholestyramine acts in this manner and can complex... 

In addition to above phenomena, there is the sizable contribution of hydrophobic effects in our nanoparticulate system. As the opposite charges of interacting molecules are neutralized, and hydrophobicity rises, the particle is instantaneously formed. This is supported by our observations on the effect of ionic strength (Fig. 18), leading to an enhancement of release when the salt concentration is lowered. Hydrophobic interactions, in addition to ionic forces, were identified as an important mechanism for drug release from ion exchange resin [64], from the CT/TPP complex [62] and from theoretical calculations of forces involved in the assembly of polyelectrolytes [65]. 

Excipients used in the formulation usually include a mixture of a water-soluble polymer and a crystalline sugar. Mannitol and natural polysaccharides such as gelatin and alginates are used. Microencapsulation and complexation with ion exchange resins can be combined with additional flavors and sweeteners for taste masking of bitter drugs. The fairly complex nature of manufacture and scale-up contributes to... 

The history of the use and identification of Cannabis sativa L. is long and complex. It is one of the oldest cultivated plants, used for the production of oil from the seeds, and fibre from the stems for rope and fabrics, and has long been used as a psychoactive drug due to the presence of cannabinoids in the resins produced by the plant. Indeed, there is evidence of cannabis use from Neolithic burial sites. The name Cannabis sativa was first used in Linnaeus Genera Plantarum in 1753, but since that publication there has been considerable debate about the number of species and varieties that exist - this has been recently summarized succinctly by Gigliano [1]. The debate has centred on (i) the characteristics of the fruit, and (ii) meiosis and pollen fertility. It is now generally accepted, however, that there is only one species, namely Cannabis sativa L., which exhibits great diversity due to both selection in the wild and in the cultivated environment. 

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