Drug packaging materials paper

The most common applications of paper, paper-board, and cardboard are in blister lidding stock and in over-the-counter (OTC) outer packaging. Because paper, paperboard, and cardboard offer virtually no moisture or gas barrier, they are typically part of the secondary pharmaceutical container. To provide additional protection, paper can be laminated or coated with a variety of materials. More commonly, when paper is involved in critical packaging functions, it is the only one component of a multicomponent system that offers optimal environmental protection to the drug environment. ... 

Secondary packaging components are not intended to make contact with the dosage form. Examples are cartons, which are generally constructed of paper or plastic, and overwraps, fabricated from a single layer of plastic or from a laminate made of metal foil, plastic, and/or paper. In special cases, secondary packaging components provide some additional measure of protection to the drug product. In such cases it could be considered a potential source of contamination and the safety of the raw materials should be taken into consideration. 

Paper, paperboard, and cardboard containers are used ubiquitously in pharmaceutical manufacturing. Because these types of containers are rarely designed to interact with the drug product itself, they are not as comprehensively validated in most compendial evaluations. Paper, paperboard, and cardboard are very inexpensive easy to print identification, instructions, or advertising materials and easily adhered to other packaging components. Furthermore, paper is a key component in several designs implemented to comply with tamper-resistant packaging mandates. ... 

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