Drug Metabolism Pharmacokinetics

Blume HH, Schug BS. Biopharmaceutical characterization of herbal medicinal products are in vivo studies necessary Eur J Drug Metabol Pharmacokinet 2000 25 41—48. 

K. Hosoya, M. Tomi, M. Takayama, Y. Komokata, D. Nakai, T. Tokui, K. Nishimura, M. Ueda, M. Obinata, S. Hori, S. Ohtsuki, G. L. Amidon, and T. Terasaki. Transporter mRNA expression in a conditionally immortalized rat small intestine epithelial cell line (TR-SIE). Drug Metabol. Pharmacokinet. 19 264-269 (2004). 

Wojcicki J, Sulikowski T, Wojcicki M, Drozdzik M, Gawronskaszklarz B, Barcewwisz-niewska B, Skowron J, Rozewicka L, Goldyn U (1995) Eur J Drug Metabol Pharmacokinet 20 119... 

Bauerova K, Matusova D, Kassai Z. Chemical enhancers for transdermal drug transport. Eur J Drug Metabol Pharmacokinet 2001 26 84-94. 

Hadgraft J. Recent developments in topical and transdermal delivery. Eur J Drug Metabol Pharmacokinet 1996 21 165-173. 

Baillie, T. A. 1992. Advances in the application of mass spectrometry to studies of drug metabolism, pharmacokinetics and toxicology. Int. J. Mass Spectrom. Ion Proc., 118/119, 289-314. 

Drug Metabolism, Pharmacokinetics and Safety A company of the Sanofi-Aventis Group Vitry-Alfortville France... 

Sharing information cross-functionally (DS, drug substance DP, drug product DMPK, drug metabolism pharmacokinetics EDD, early drug discovery)... 

The subsequent chapters describe the role of mass spectrometry in the drug discovery process in greater detail. Initial chapters deal more with instrumentation and sample preparation as they relate to mass spectrometry. The remaining chapters describe the utility of mass spectrometry in different areas of the drug discovery process, such as combinatorial chemistry, drug transport, drug metabolism, pharmacokinetics, and microdialysis. 

Drug metabolism/pharmacokinetics (DMPK) evaluating the metabolic and pharmacokinetic profiles of the drug candidates in animal models and human clinical studies. 

Since the 1977 review in Annual Reports, the applications of stable-isotope-labeled compounds to biomedical research have increased dramatically. Three international conferences devoted to the use of stable isotopes in the life sciences and one to synthesis and general applications have been held. Review articles have focused on mass spectrome-tric-based analytical methods, on applications of stable isotopes in clinical and pharmacological research, and on more specific studies concerning problems in drug metabolism, pharmacokinetics and synthesis. The present review covers mainly the literature published since 1981 and focuses on recent developments in the use of stable isotopes for investigations of drug metabolism and disposition. 

Shah V P, Midha K K, Dighe S, et al. (1991). Analytical methods validation Bioavailability, bioequivalence and pharmacokinetics studies. Conference Report. Eur. J. Drug Metabol. Pharmacokinet. 16 249-255. 

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