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Drug-targeting efficiency

Leptin has proved to be an efficient treatment for the rare form of obesity associated with leptin deficiency. By contrast, the results of the fust clinical trial with human leptin in obese patients (without leptin deficiency) were less promising. This may be explained by leptin resistance in a high proportion of these patients. However, the mechanisms involved in the development of leptin resistance could become new drug targets. [Pg.161]

Polymeric microparticles have been studied and developed for several years. Their contribution in the pharmacy field is of utmost importance in order to improve the efficiency of oral delivery of drugs. As drug carriers, polymer-based microparticles may avoid the early degradation of active molecules in undesirable sites of the gastrointestinal tract, mask unpleasant taste of drugs, reduce doses and side effects and improve bioavailability. Also, they allow the production of site-specific drug targeting, which consists of a suitable approach for the delivery of active molecules into desired tissues or cells in order to increase their efficiency. [Pg.61]

Gregoriadis G, Saffle R, Hart SL. High yield incorporation of plasmid DNA within liposomes effect on DNA integrity and transfection efficiency. J Drug Target 1996 3 469 75. [Pg.243]

The pharmacokinetic processing of macromolecules used as targeting devices or drug carrier systems is different from that of conventional cytotoxic drugs and plays an important role in e.g. the targeting efficiency of these cytotoxic agents coupled to the macromolecules. [Pg.205]

As mentioned in Section 8.4.2, elevated interstitial pressure, heterogeneous and reduced functional vasculature, and the relatively large distances that Mabs have to travel in the tumour interstitium, are hurdles which need to be overcome in the pursuit of efficient drug targeting. The relatively large molecular weight of Mabs (approximately 150 kDa) [2,14], also... [Pg.210]

The distribution and elimination characteristics of the active drug have a profound influence on the efficiency of drug targeting. This topic is dealt with in Section 13.5. [Pg.354]


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Drugs targeting

Targeted drugs

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