Drug disposition absorption

Custodio JM, Wu C-Y, Benet LZ. Predicting drug disposition, absorption/elimination/ transporter interplay and the role of food on drag absorption. Adv Drag Del Reviews 2008 60 717-733. 

P. Langguth, K. M. Lee, H. Spahn-Langguth, G. L. Amidon. Variable gastric emptying and discontinuities in drug absorption profiles dependence of rates and extent of cimeti-dine absorption on motility phase and pH. Biopharm. Drug Disposit. 1994,... 

Polarized tissues directly involved in drug absorption (intestine) or excretion (liver and kidney) and restricted drug disposition (blood-tissue barriers) asymmetrically express a variety of different drug transporters in the apical or basolateral membrane resulting in vectorial dmg transport. This vectorial dmg transport is characterized by two transport processes the uptake into the cell and subsequently the directed elimination out of the cell (Figure 15.3). Because the uptake of substances... 

Keywords Isolated perfused lung Absorption Permeability Instillation Aerosolisation Drug disposition In vitro-in vivo correlation... 

The following sections provide an overview of the application of the IPL for the study of drug absorption. Examples are provided to illustrate the use of the IPL to study drug permeability, absorption profiles, transport mechanisms and the effects of inhaled dose formulation on drug disposition. 

Wu C-Y, Benet LZ (2005) Predicting Drug Disposition via Application of BCS Transport/Absorption/Elimination Interplay and Development of a Biopharmaceu-tics Drug Disposition Classification System. Pharm. Res. 22 11-23... 

Chiou, W.L. (1994) Effect of unstirred water layer in the intestine on the rate and extent of absorption after oral administration. Biopharmaceutics ei Drug Disposition, 15, 709-717. 

Wu, C.Z. and Benet, L.Z. (2005) Predicting drug disposition via application of BCS transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharmaceutical Research, 22, 11-23. 

At birth, term infants can metabolize and eliminate drugs. For most patients these systems did not function during fetal life and therefore even at birth are not very efficient. Table 6.1 outlines the time required for maturation of some of the systems used in drug absorption and elimination. Table 6.2 lists other factors that alter drug disposition in newborns. The ability to absorb and eliminate drugs increases slowly over the first month of life. 

Pharmacokinetics and pharmacodynamics form the two major branches of pharmacoiogy. Pharmacokinetics is the study of drug disposition and deais with the processes of absorption, distribution, metaboiism and eiimination. Pharmacodynamics is concerned with the reiationship between the concentration of a drug and its effect. Put another way, pharmacodynamics is what a drug does to the body whiie pharmacokinetics is what the body does to a drug. This chapter wiii cover the generai principies reiating to these processes, and deveiop some of the principies that describe their kinetics and dynamics. 

Macheras, P. and Symillides, M., Toward a quantitative approach for the prediction of the fraction of dose absorbed using the absorption potential concept, Biopharmaceutics Drug Disposition, Vol. 10, No. 1, 1989, pp. 43-... 

Subpart (a)—Pharmacology and Drug Disposition This section should describe the pharmacologic effects and mechanism(s) of action of the drug in animals and information on the absorption, distribution, metabolism, and excretion of the drug, if known. 

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