Biopharmaceutics Drug Disposition Classification System

Figure 10.8 Predictability of systemic exposure profile using a PBPK approach and Biopharmaceutics Drug Disposition Classification System (adapted from Wu and Benet [24]).

Wu, C.Z. and Benet, L.Z. (2005) Predicting drug disposition via application of BCS transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharmaceutical Research, 22, 11-23. 

Wu CY, Benet LZ. Predicting Drug Disposition via Application of BCS Transport/ Absorption/Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System. Pharm Res 2005 22 11-23. 

Benet LZ (2013) The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development. J Pharm Sci 102(l) 34-42... 

It has recently been proposed that the Biopharmaceutical Classification System (BCS) can be used to predict intestinal drug disposition with regards to efflux transport and metabolism (339). Furthermore, on the basis of the key substrate BCS-related properties, permeability, and solubility, the system may be used to predict potential interactions mediated through changes in efflux and/or metabolism at the level of the intestine. 

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