Drug design/development

Zimmermann, M., Tresch, A., Maass, A., Hofmann, M. Drilling into a HTS data set of E. coli dihydrofolate reductase. In Proceedings of the 15th European Symposium on Quantative Structure-Activity Relationships 2004, Aki E., Yalcin J. (eds) published by Computer Aided Drug Design Development Society, Turkey,... 

Having introduced the key NMR parameters, we now describe in more detail how NMR can contribute to the drug-design/-development process. Figure 1 summarizes the ways in which various types of NMR experiments can contribute. We have arranged the diagram to reflect three elements namely the peptide, the receptor, and their binding interaction. 

I. Yalcin eds., Computer Aided Drug Design Development Society in Turkey, Turkey, 2004, 25 29. 

The development of new separation methods for the analysis of drugs is continuously requested during drug design, development, production, and use. In this regard, some analytical issues are of particular importance, including purity assessment, analysis of isomers, detection of impurities, and/or related compounds. Although most of the methods used for pharmaceutical analysis involve... 

Hibert, M.F., Gittos, M.W., Middlemiss, D.N., Mir, A.K., Fozard, J.R., 1988. Graphics computer-aided receptor mapping as a predictive tool for drug design development of potent, selective, and stereospecific ligands for the 5-HT receptor. J. Med. Chem. 31, 1087-1093. 

M. F. Hibert, M. W. Gittos, D. N. Middlemiss, A. K. Mir, and J. R. Fozard, /. Med. Chem., 31,1087 (1988). Graphic Computer-Aided Receptor Mapping as a Predictive Tool for Drug Design Development of Potent, Seleaive and Stereospecific Ligands for the 5-HTij Receptor. 

Sakr FM, Gado AM, Mohammed HR, and Adam AN. (2013). Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology A pilot study. Drug Design Development and Therapy, 1,413—423. 

This work was supported by the Center for Drug Design, Development, and Delivery (CD4) Graduate Assistance in Areas of National Need (GAANN) Fellowship awarded to S.P.S. and a National Science Foundation CAREER award to J.S.T. (CBET-0746209). 

David J. Craik, Centre for Drug Design Development, University of Queensland, Brisbane 4072, Queensland, Australia... 

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