Drug design/development natural products

Most researchers and drug companies, however, still appear to he conhdent that combinatorial chemistry holds untold promise for the future. Though they often admit that there is little to show hy way of approved products that have evolved from combinatorial techniques, they point out that the early years of new technologies are often marked by similar stories of limited success. Eventually, they say, comhinatorial chemistry will take its place with natural products, trial and error, serendipity, and other traditional roads to drug development as an essential tool in the design and production of new pharmaceutical products. 

Natural Product Scaffolds and Protein Structure Similarity Clustering (PSSC) as Inspiration Sources for Compound Library Design in Chemogenomics and Drug Development... 

An example of a leading chemical CRO is Albany Molecular (AMRI). It had chemistry revenues 184 million in 2005. AMRI does organic synthesis and chemistry development, supported by computational chemistry for molecular modeling, with computer-assisted drug design. Furthermore, it offers different types of libraries custom, semiexclusive, focused, and natural products. Finally, AMRI conducts its own proprietary R D aimed at licensing preclinical and clinical compounds. 

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