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Drug design/development bioisosteres

While bioisosterism had been comprehensively treated in several printed reviews dealing with common replacements used in analogue design, computer databases allowing (sub)structure searches were slow to appear. Toshio Fujita was the first to tackle this problem and, in the early 1990s, developed EMIL (Example-Mediated Innovation for Lead Evolution), an expert system built around a knowledge base of thousands of consecutive structural modification patterns for several drug and pesticide classes described in the literature [12, 13]. ... [Pg.57]

See other pages where Drug design/development bioisosteres is mentioned: [Pg.542]    [Pg.648]    [Pg.298]    [Pg.3]    [Pg.137]    [Pg.217]    [Pg.223]    [Pg.224]    [Pg.301]    [Pg.373]    [Pg.82]    [Pg.110]    [Pg.870]    [Pg.298]    [Pg.43]    [Pg.91]    [Pg.56]    [Pg.17]   
See also in sourсe #XX -- [ Pg.221 , Pg.301 , Pg.328 ]



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Bioisostere

Bioisosteres

Bioisosteres/bioisosterism

Bioisosteric

Bioisosterism

Drug bioisostere

Drug bioisosterism

Drug design/development

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