Drug delivery systems attributes

Table 7 Ideal Attributes of a Drug-Delivery System... 

There is some confusion concerning terminology used for drug delivery when control of drug release is discussed. Within this chapter we will use an empirical approach. When a drug-delivery system does not contain any design element (formulation or process attribute) that is included to modify either spatial or... 

When new drugs and drug-delivery systems are developed in the laboratory, the correlation of the necessary production equipment may be very difficult indeed. For example, the shear needed to create the desired particle size of an emulsion with the help of laboratory equipment may pose serious problems in the selection of plant equipment necessary to reproduce the attributes of the product. Recording the speed of a laboratory mixer is not sufficient by itself for this task definition of the operating principle and equipment design is necessary to accomplish the task. 

The basic theory of spray drying is well understood and enables excellent control of the critical variables which affect product attributes. Judging by the number of recent publications described in the present chapter, which is not exhaustive by any means, one can conclude that spray drying is a process that meets the demand of sophisticated drug delivery systems through an efficient, one-step process capable or precise particle size and drug content control. 

Wokovich AM et al. (2006) Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quahty attribute. Fur J Pharm Biopharm 64 1-8... 

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