Drug delivery mechanisms

Song, Y., et al. 2004. Mucosal drug delivery Mechanisms, methodologies, and applications. Crit... 

One difficulty with the cytotoxic agents that are used for the treatment of cancer is the differentiation of cytotoxicity between target tumor cells and normal cells. In an innovative approach, the Wyeth group took advantage of a tumor cell-specific drug delivery mechanism of antibodies. They conjugated calicheam-icin (93), perhaps the best described member of the ene-diyne... 

Drug delivery mechanisms-new approaches to delivering therapeutic agents at the desired dose to the desired site in the body. 

It should be noted that collagen sponges offer an ideal local drug delivery mechanism. Their porosity and absorptive properties make them well tailored for topical application of substances during surgery. While this has been classically taken advantage of for delivery of hemostatic agents, other bioactive substances have also been... 

M. D. Chavanpatil, A. Khdair and J. Panyam, Nanoparticles for cellular drug delivery mechanisms and factors influencing delivery. /. Nanosci. NanotechnoL, 6(9-10), 2651-2663 (2006). 

Based on the methods of production and with an eye on the final applications of the MIPs, which can range from selective removal or detection of target species to chromatographic and sol phase separations and drug delivery mechanisms, MIPs are produced in different physical forms and structures, ranging from films and beads to... 

Robinson, J.R. Ocular drug delivery mechanism(s) of corneal drug transport and mucoad-hesive delivery systems. STP. Pharm. Sci. 5(12), 839-846 (1989)... 

An analogy between this mechanism and a drug delivery mechanism can be made. The fullerenes are active only in the contact area, by releasing their active substance (individual layers). Figure 2.100 schematically represents the release of the individual layers in the tribological contact. 

DRUG DELIVERY MECHANISMS 8.2.1 Release by Breakup after Swelling... 

There are myriad mechanisms to direct the release of drugs in a controlled manner. We can classify the drug delivery mechanisms of special interest in tissue engineering into three main categories diffusion from nondegradable systems, bioerodible systems, and stimuli-responsive systems. Several other strategies have been employed to create desirable release profiles however, an exhaustive description is certainly beyond the scope of this chapter, and may be found in excellent reviews in the literature (Caldorera-Moore and Peppas 2009, hanger and Peppas 2003, Lavan et al. 2003, Saltzman and Olbricht 2002). 

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