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Drug delivery dental diseases

Controlled and sustained drug delivery has recently begun to make an impression in the area of treatment of dental diseases. Many researchers have demonstrated that controlled delivery of antimicrobial agents, such as chlorhexidine [128-130], ofloxacin [131-133], and metronidazole [134], can effectively treat and prevent periodontitis. The incidence of dental caries and formation of plaque can also be reduced by controlled delivery of fluoride [135,136]. Delivery systems used are film-forming solutions [129,130], polymeric inserts [132], implants, and patches. Since dental disease is usually chronic, sustained release of therapeutic agents in the oral cavity would obviously be desirable. [Pg.521]

Site-specific drug delivery, which has the potential for local (topical) therapy of several conditions, such as aphthous stomatitis, gastric ulcer, esophageal cancer, toothache, and dental sores, as well as the potential for the treatment of systemic diseases such as diabetes mellitus and angina pectoris. ... [Pg.1254]

The initial results demonstrate that molecular prototype delivery systems are able to harness free radical reactivity within the laboratory. Proof of the concept has also highlighted the importance, as well as plausibility, of innovative development of functional dental restorative materials that have bioactive and bonding properties suitable for use in dentin and enamel that also show beneficial preventative and therapeutic properties [215,216]. Further evaluation is required in the application of these novel drug-delivery systems for the prevention and treatment of disease states mediated by free radicals. [Pg.399]


See other pages where Drug delivery dental diseases is mentioned: [Pg.395]    [Pg.872]    [Pg.83]    [Pg.53]    [Pg.176]    [Pg.1131]    [Pg.145]    [Pg.37]    [Pg.349]    [Pg.185]   
See also in sourсe #XX -- [ Pg.37 ]




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