Drug delivery and targeting system

Adamantane derivatives can be employed as carriers for drug delivery and targeting systems. Due to their high lipophUicity, attachment of such groups to drugs with low hydrophobicity could lead to a substantial increase of drug solubihty in lipidic membranes and thus increases of its uptake. 

Use the appropriate terminology to describe drug delivery and targeting systems... 

Table 5.2 Components of a drug delivery and targeting system (DDTS) ...

Dosage forms for advanced drug delivery and targeting systems 61... 

Notwithstanding the plaints above, the last question must be discussed can a delivery system be used to overcome conditions imposed by the biological system (excluding those posed by the route of administration) to achieve optimized therapy Two major approaches to this end have been proposed regional drug delivery and targeted drug delivery. 

Crommelin, D. J. A., Hennink, W. E., and Storm, G. Drug targeting systems Fundamentals and applications to parental drug delivery, in Hilleiy, A. M., Lloyd, A. W., and Swarbrick, J., (eds.), Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists. London Taylor and Francis, 2001. 

Alexander Florence is Dean of The School of Pharmacy at the University of London he was previously James P. Todd Professor of Pharmaceutics at the University of Strathclyde. His research and teaching interests are drug delivery and targeting, dendrimers, nanoparticles, non-aqueous emulsions, novel solvents for use in pharmacy and general physical pharmaceutics. He co-authored the book Surfactant Systems their Chemistry, Pharmacy and Biology with David Attwood. 

Daan JA, Hennink WE, Storm G (2002) Drug targeting system fundamentals and applications to parenteral drug delivery In HiUery AM, Lloyd AW, Swarbrick J (eds) Drug delivery and targeting for pharmacists and pharmaceutical scientists. Routledge, UK... 

Li H, Sun H, Zhong MQ. The role of the transferrin-transferrin-receptor system in drug delivery and targeting. Trends Pharmacol Sci 2002 23 206-209. 

Drug Delivery. Philadelphia Taylor Francis. ISSN 1071-7544. Covers basic research, development, and application principles of drug delivery and targeting at molecular, cellular, and higher levels. Topics covered include all delivery systems and modes of entry, such as controlled release systems microcapsules, liposomes, vesicles, and macromolecular conjugates antibody targeting and protein/peptide delivery. Peer-reviewed. 

Torehilin et al. used a similar approach to introduce enzymes into liposomes [65]. Formation of a surfactant-antibody conjugate as reported by Kabanov et al. [84] made it possible to link antibodies into micelles (which were formed by classical surfactants), which could solubilize hydrophobic probe molecules. These systems were suggested for drug delivery and targeting. 

Sah,H. andChien, Y.W., Rate control in drug dehvery and targeting fundamentals and applications to implantable systems, in Drug Delivery and Targeting, Hillary, A.M., Llyod, A. W., and Swarbrick, k, Eds., London, Taylor Francis Ltd., 83-115,2001. 

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