Drug abuse bupropion

Drug abuse and dependence Studies in healthy volunteers, subjects with a history of multiple drug abuse, and depressed patients showed some increase in motor activity and agitation/excitement. In individuals experienced with drugs of abuse, a single dose of 400 mg bupropion produced mild amphetamine-like activity as compared with placebo. 

Drug abuse The abuse potential of tesofensine has been studied in a single-dose, double-blind, randomized, placebo-controUed, crossover study in comparison with D-amfetamine (as a positive control for dopaminergic/stimulant effects) and bupropion and atomoxetine (as negative/unscheduled controls) in 52 users of recreational stimulants [100. The effects of D-amfetamine were significantly greater than those of placebo on all primary and secondary subjective measures. The effects of... 

Drug abuse A 30-year-old woman crushed up to eight tablets of bupropion 150 mg and insufflated them to experience a high when cocaine was unavailable to her [38" ]. 

Drug abuse Although bupropion has been previously described as a drug of low abuse potential, sporadic reports of abuse continue to appear. The desired effect in bupropion abuse would appear to be related to the amphetamine-like effects of this agent on the dopamine and noradrenaline systems, resulting in increased arousal and euphoria, with these effects achieved more rapidly via parenteral administration whereby first-pass metabolism is avoided. 

A 19-year-old white male with a history of multiple drug abuse, psychosis, depression and attention-deficit hyperactivity disorder used an unknown quantity of MXE IV for abuse shortly before he was discharged from an inpatient detoxification facility. He was on bupropion, aripiprazole and chlorprothixene. About 30 min after the injection, he presented to the ER of the hospital with extreme agitation, ataxia and semistuporous state. 

Costall B, Jones BJ, Kelly ME, Naylor RJ, Onaivi ES, Tyers MB (1990b) Sites of action of ondansetron to inhibit withdrawal from drugs of abuse. Pharmacol Biochem Behav 36 97-104 Cryan JF, Bruijnzeel AW, Skjei KL, Markou A (2003) Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat. Psychopharmacology 168 347-358... 

Dopamine-Stimulating Medications. A variety of drugs that increase the availability of dopamine have been studied in cocaine addicts including L-DOPA, bupropion, amantadine, and methylphenidate. In small uncontrolled trials, these have shown some benefit, but definitive studies have yet to be performed. In addition, some dopamine-stimulating medications (in particular, the stimulants like methylphenidate or the amphetamines) are themselves subject to abuse, though, of note, this is typically not a problem when they are prescribed to patients who do not have a history of substance abuse such as, for example, in the treatment of attention deficit-hyperactivity disorder. 

Atomoxetine, bupropion, and TCAs are second-line alternatives to the stimulants for treatment of ADHD in children, teens, and adults. The potential benefits of these agents in comparison with stimulants include reduced risk of abuse and somewhat lower potential for sleep disturbance. TCAs are the most dangerous in overdose and pose the greatest risk for cardiovascular side effects. The monoamine oxidase inhibitor tranylcypromine is effective but used infrequently due to the potential for dangerous drug and dietary interactions. Selective serotonin reuptake inhibitors (SSRIs) are not effective for ADHD. ... 

Answer B. Buspirone has selective anxiolytic activity that is slow in onset The drug has no abuse liability and will not suppress withdrawal symptoms in patients who have become physically dependent on barbiturates, benzodiazepines, or ethanol. Bupropion is an antidepressant, also approved for management of dependence on nicotine. Baclofen is a spinal cord muscle relaxant that activates GABAfi receptors. Buprenorphine is a long-acting opioid analgesic with no effectiveness in GAD, and butabarbital is a barbiturate that may cause dependence. 

A review of bupropion abuse describe six reported cases, five of which involved nasal insufflation, three involving seizure precipitation and one case of deliberate oral misuse in a child. Case reports, clinical and correctional experience indicate that bupropion is frequently abused in correctional settings [72. Further case reports of intranasal bupropion abuse have since been described in patients with correctional system exposure, or where frequent drug screening may militate against the use of other drugs [73. ... 

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