Drew studies

Drew LR, Hodgson DM, Griffiths KM (1999). Clozapine in community practice a 3-year follow-up study in the Australian Capital Territory. Aust NZ J Psychiatry667-75. 

Another study drew a comparison between the polymerisation of ethylene oxides and propylene oxides in similar operating conditions and in the presence of 10% of sodium hydroxide. When the polymerisation reached its maximum speed, the temperature reached 439°C for the former and 451 °C for the latter the pressures obtained are 44.6 and 26.6 bar respectively. 

It was real-time XPS studies of oxygen chemisorption at magnesium, aluminium and copper that drew attention to the possible role of oxygen transients... 

Spectroscopic studies during the period 1986-1990 drew attention through coadsorption studies to transient oxygen states existing when a dioxygen... 

The formation of purines in interstellar space has been considered feasible for some considerable time. A theoretical study (using ab initio methods) on the mechanism of adenine formation from monocyclic HCN pentamers has been reported and has afforded a deeper insight into the gas-phase chemistry of possible purine syntheses. The authors drew the following conclusions from their results ... 

Studies involving 2,6-diacetylpyridine derivatives. Detailed studies by Nelson and coworkers supported by X-ray structural work by Drew and coworkers have elucidated many aspects of the template synthesis of metal complexes of a Schiff-base ligand series which includes the N4-donor system (83) and the N5-systems (84)-(86) (Nelson, 1980). Since... 

In terms of the approach used, the authors drew a general conclusion that the [3+ 2]-cycloaddition reactions of nitronates with dipolarophiles under study should be considered as either nonconcerted or as those, which substantially differ in the positions of transition states on the reaction coordinate (337). 

To explore the validity of the ring formation strategy, we drew up plans and carried out an enantioselective synthesis of diene 77 (Scheme 19). Initially, based on previous studies on similar medium- and large-ring syntheses, we surmised that elevated temperatures would be necessary for effective macrocycliza-... 

Many inhalation exposure techniques, such as the whole-body, nose-only, mouth-only, or head-only technique (Drew and Laskin, 1973 MacFarland, 1976 Leong et al., 1981 Phalen, 1984 Nelson, 1980), the intranasal exposure technique (Elliott and DeYoung, 1970 Smith et ah, 1981), the endotracheal nebulization technique (Leong et ah, 1985, 1988 Schreck et ah, 1986), and the body plethysmographic techniques (Alarie, 1966 Thome and Karol, 1989), have been developed for inhalation toxicity studies. Table 10.2 provides a summary of the advantages and disadvantages of each of the major inhalation exposure methodologies. 

The new treatment had its origins partly in ab initio molecular orbital calculations of substituent effects and partly in extensive studies of gas-phase proton transfer reactions from about 1980 (Section V.A). Various aspects of this work essentially drew attention to the importance of substituent polarizability. In 1986 Taft, Topsom and their colleagues252 developed a scale of directional substituent polarizability parameters , oa, by ab initio calculations of directional electrostatic polarization potentials at the 3-21G//3-31G level for a large set of CH3X molecules. The oa values were shown to be useful in the correlation analysis of gas-phase acidities of several series of substrates252, and such work has subsequently been extended by Taft and Topsom151. 

Miller DS, Nobmann S, Gutmann H, Drewe J, Fricker G (2000) Xenobiotic transport in isolated brain microvessels studied by confocal microscopy. Mol Pharmacol 58 1357-1367... 

Studies in animals indicate that acute exposures to levels of 160-980 ppm may be lethal (Alexeeff et al. 1985 Eustisetal. 1988 Flonmaetal. 1985 Flurtt et al. 1987a Irish etal. 1940 Katoetal. 1986). Several studies reveal there is an extremely narrow margin between lethal and nonlethal exposures. For example, Kato et al. (1986) found no deaths in rats exposed to 700 ppm for 4 hours, but 100% lethality in animals exposed to 800 ppm. Similarly, Irish et al. (1940) found 100% survival in rats exposed to 100 ppm for 24 hours, and 100% lethality at 220 ppm. Longer-term exposures of animals can lead to death after exposure to levels as low as 66-120 ppm (Drew 1984 Flaber 1987 Flardin et al. 1981 Irish et al. 1940 Reuzel et al. 1987). 

Hematological Effects. Hematological effects have not been observed in humans exposed to bromomethane (Johnstone 1945 Kantarjian and Shasheen 1963 Longley and Jones 1965 O Neal 1987 Viner 1945 Wyers 1945). In animals, decreased red and white blood cell counts were noted in one study of rats exposed to 160 ppm (Eustis et al. 1988), but hematological effects were not detected by others (Drew 1984 Haber 1987 Kato et al. 1986 Reuzel et al. 1987). These studies indicate that blood and blood-forming cells are not important target tissues for bromomethane. 

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