Xenobiotics transporters

Xenobiotic Transport Mechanisms and Pharmacokinetics in the Dogfish Shark... 

Miller DS, Nobmann S, Gutmann H, Drewe J, Fricker G (2000) Xenobiotic transport in isolated brain microvessels studied by confocal microscopy. Mol Pharmacol 58 1357-1367... 

Pritchard, J.B. and Miller, D.S. Expression systems for cloned xenobiotic transporters. Toxicol Appl Pharmacol 204 256-262, 2005. 

Table 3 Nuclear Receptors Involved in the Induction of Xenobiotic Transporters...

Figure 15.2. Location of xenobiotic transporters in selected barrier and excretory tissues. For simplicity, the tissues are arranged along a structure representing the vascular space. Arrows indicated direction of transport under normal conditions. This figure is not meant to be comprehensive not all transporters expressed in a tissue are shown. Transporters driven by ATP pump substrates out of cells (efflux). Other transporters are capable of supporting substrate uptake or efflux. Which of these processes predominates depends on available driving forces—for example, substrate concentration gradient and the capability to couple transport to sources of potential energy.

Figure 15.3. Substrate selectivity and energetics of major xenobiotic transporters.

Leabman MK, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE et al. Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics 2002 12 395-405. 

Cooper, P.S., W.K. Vogelbein and P.A. Van Veld. Altered expression of the xenobiotic transporter P-glycoprotein in liver and liver tumours of the mummichog (Fundulus heteroclitus) from a creosote-contaminated environment. Biomarkers 4 48-58, 1999. 

Albertus, J.A. and R.O. Laine. Enhanced xenobiotic transporter expression in normal teleost hepatocytes response to environmental and chemotherapeutic toxins. J. Exp. Biol. 204 217-227, 2001. 

Bain, L.J., J.B. McLachlan and G.A. LeBlanc. Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein. Environ. Health Perspect. 105 812-818, 1997. 

Miller, D.S., S.N. Nobmann, H. Gutmann, M. Toeroek, J. Drewe and G. Fricker. Xenobiotic transport across isolated brain microvessels studied by confocal microscopy. Mol. Pharmacol 58 1357—1367,2000. 

Zimniak, P., S. Pikula, J. Bandorowicz-Pikula and Y.C. Awasthi. Mechanisms for xenobiotic transport in biological membranes. Toxicol. Lett. 106 107—118, 1999. 

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