Dressing Preservative Agents

Chlorhexidine diacetate is partially soluble in water, and the solubility increases with temperature, which provides a particulate form for application, and 

Chlorhexidine is most effective against microorganisms in the solid form compared to a solution preparation. 

The images in Fig. 2.25 demonstrate the moisture/blood absorption of the absorbable polymer, and a particulate size (50-200 pm) was chosen to visibly observe and photograph the growth in size of the particulate. However, a 5-15 pm size would better coat the nonlinear surface of tissue. 

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Shelf stability of a product is of critical importance because it is affected by longterm antimicrobial and antioxidizing activity enhanced by preservative agents compared to only antimicrobial agents that are added to dressings for thwarting infection in a wound. Preferably, a preservative can be added to a product that possesses broad-spectrum antimicrobial activity that will allow the product to maintain activity before reaching a planned expiration date, and prevent infection when applied to wounds. 

Salt Salt has been a known preservation agent for centuries. Its use in dressings complements vinegar and other preservatives in producing shelf-stable dressing products. Salt also serves as an important source of zesty flavor as well as a flavor enhancer for a number of other ingredients. 

In a microorganism prone environment, it is preferable to protect a dressing with a preservative such as chlorhexidine to prevent the contamination of the dressing. It is necessary to consider the solubility of an agent in the liquid phase of the dressing during the selection of an antimicrobial agent. The formulated polyvinyl acetate and polybutyral materials were dissolved in ethanol that is also a solvent for chlorhexidine diacetate. The information (Block, 2001) in Table 2.12 provides solubilities of chlorhexidine compounds in different solvents. 

From inspection of Table 2.12, it is apparent that only chlorhexidine diacetate is sufficiently soluble in ethanol, so the liquid applied barrier dressing consisting of polymers dissolved in ethanol must be preserved by chlorhexidine diacetate, because water is not an option. The concentration of this agent is another consideration, but the range of options is clear from the above table. 

Use Mayonnaise, salad dressings, pickled foods, preservative, medicine (antifungal agent), latex coagulant. 

Products and Uses An ingredient in salad dressings, margarines, mayonnaise, spreads, processed vegetables and fruits, soft drinks, and canned shellfish. As a preservative in foods. In medicine it is used as a chelating agent for treatment of lead poisoning. 

Polymer nanofibers for biomedical and biotechnological applications such as tissue engineering, controlled drug release, wound dressing, medical implants, nanocomposites for dental restoration, molecular separation, biosensors, and preservation of bioactive agents were reviewed. ... 

Uses Emulsifier, suspending agent, thickener, stabilizer, binder in foods, cosmetics, pharmaceuticals, industrial applies. adhesives leather dressing textile printing and sizing dyes hair-wave preps. printing inks food preservative, formulation aid, cryst. inhibitor pharmaceutical tablet excipient and binder in dentifrices... 

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