Drag carrier delivery systems

The process of phagocytosis is of particular relevance when particulate delivery systems, such as microspheres, liposomes and other advanced delivery systems (described in Chapter 5), are used. Such particulate carriers are susceptible to MPS clearance. Sequestration by the MPS is useful in some cases, for example in the treatment of certain microbial diseases. However, if the drag is to be delivered to sites other than the MPS, it is highly undesirable. Therefore considerable research effort is being directed towards methods of avoiding MPS uptake of drag delivery systems. Strategies to both exploit and avoid MPS uptake are described in detail in Chapter 5 (see Section 5.1.4). 

The main opportunity for advanced drag delivery systems in this market is in the area of targeted drag delivery. Current research is focused on the development of carriers such as liposomes and on the use of monoclonal antibodies as targeting agents (see Sections 5.2 and 5.3). The eventual market opportunity is considerable—cancer is still one of the commonest fatal diseases, and some of the most deadly forms are resistant to available therapies. The potential market for effective targeting delivery systems may eventually exceed 5 billion. Whether, and how soon, it achieves this figure will depend on the speed with which successful products come to market. 

Much effort is also currently being expended on the development of novel drag delivery systems for pulmonary drag delivery. By employing a colloidal carrier in which drag is dispersed, it is possible to control ... 

Habib, W., Khankari, R., and Hontz, J. (2002), Fast-dissolve drag delivery system, Crit. Rev. Therap. Drug Carrier Syst., 17, 61-72. 

Lloyd JB. Soluble polymers as targetable drag carriers. In Johnson P, Llyod JG, eds. Drag Delivery Systems Fundamental and Techniques. Chichester, U.K., and Weinheim, Germany Ellis Horwood and VCH Verlagsgesellschaft, 1987 95. 

B Narasimhan. NA Peppas. Molecular analysis of drag-delivery systems controlled by dissolution of the polymer carrier. J. Pharm. Sci. 86 297-.304, 1997. 

Pharmaceutically, guar gum is widely used as a colon-specific drug carrier in the form of matrix and compression-coated tablets as well as microspheies. Table 1 summarizes type of dosage form, drag, chemical composition, and drug release profiles of some delivery systems made of guar giun. 

The choice of a suitable drag carrier is a critical factor for controlling the release rate of the drag [21]. In the past years, controlled drug delivery has been developed in polymer-based systems (e.g., biocompatible polymeric matrices, mixture of polymers, and polymer-based composites such as ceramics or bioactive glasses)... 

In the previous chapter, two examples of multifunetional drag delivery systems applying PSi luminescent and photonic properties were described, but there are many other possibilities to include additional functionalities to the delivery systems. One of the most studied applications is PSi-poljuner composite structures in which PSi have a dual role as a hydroxyapatite growth activator and drag carrier (Mukheijee et al. 2006 Fan et al. 2009, 2011). The composite structures are described in detail in chapter Poljnner-Porous Silicon Composites. ... 

Halofantrine. a highly lipophilic antimalaiial agent, was formulated in lipid vehicles that were either a lipid solution, an emulsion, or a micellar system. Lymphatic transpon was a major contributor to oral bioavailability. The rank order effect of the vehicles for the promotion of lymphatic transport was micelles > emulsion > lipid solution (62) (Fig. 12). These overall results underline the promising properties of emulsion drug carriers as therapeutic delivery systems for a variety of drags (Table 5). 

Rajamma, A., Yogesha, H., Sateesha, S., 2012. Natural gums as sustained release carriers development of gastroretentive drag delivery system of ziprasidone HCl. DARU J. Pharm. Sci. 20, 58. 

Hamman, J.H. Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems. Mar. Drags 8, 1305-1322 (2010). doi 10.3390/md8041305... 

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