Dosages dietary considerations

In accordance with the provisions of the Dietary supplement Health and Education Act 1994, in the United States botanical dosage forms can be marketed as dietary supplements provided the label makes no medical claim however, structure-function claim is allowed. In most countries other than the United States, botanical preparations are regulated as drugs thus posing a different set of challenges. This fact must be taken into consideration in standard setting. 

Many of the animal neurotoxicity studies are complicated by a lack of reported information on aluminum content in the base diet. This is an important issue because, as discussed in the introduction to Section 2.2.2, commercial rodent laboratory feed has a high aluminum content which can significantly contribute to total exposure. Dosages in studies with insufficient information on aluminum content in the base diet therefore must be assumed to underestimate the actual experimental dosages. The magnitude of the underestimate may be considerable, particularly for maternal dietary intake during lactation (an exposure period used in many neurobehavioral studies of aluminum in mice), which can be markedly... 

Aids intended to facilitate the proper administration or use of a drug by healthcare personnel or patients, e.g. dietary guides for people with diabetes, instructions for drug use, applicators, dosage containers, may be distributed to the extent required by therapeutic considerations. 

A1 Tarazi and Alshawabkeh (2003) reported that a mixture of dietary formie and propionic acids (total concentration 2% or more in the diet) for of newly hatehed infected layer chicks significantly decreased the crop and caecal population of Salmonella pullorum and reduced mortality. Iba and Berchieri (1995) carried out experiments on the antibacterial effects of a commercial formic acid-propionic acid mixture against different salmonella serotypes, using a dosage of 0.2% in diets. After 28 days of storage, the bactericidal effect in feed was still considerable. Chickens reared on the treated feed that had been artificially contaminated with Salmonella enteritidis and Salmonella typhimurium showed no contamination in caecal contents. 

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