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Dornase

Pancrease Pancreatectomy Pancreatic a-amylase Pancreatic dornase Pancreatic elastase Pancreatic hypertrophy Pancreatic lipase Pancreatin [8049-47-6]... [Pg.719]

Dornase alfa is produced by genetically engineered Chinese Hamster ovary cells containing DNA encoding for the native human protein deoxyribunuclease I. It is purified by tangential flow filtration and column chromatography. [Pg.707]

Dornase alfa (Pulmozyme ) is a recombinant human (rh) DNase that selectively cleaves extracellular deoxyribonucleic acid (DNA). This DNA is released during neutrophil degradation and contributes to the high viscosity of CF sputum. Nebulization of dornase alfa 2.5 mg once or twice daily improves daily pulmonary symptoms and function, reduces pulmonary exacerbations, and improves quality of life.16 N-acetylcysteine and hypertonic saline are other mucolytic agents that are occasionally used however, they are not preferred agents due to a greater incidence of bronchospasm and unpleasant odor and taste.5... [Pg.250]

Pulmozyme Dornase alfa, recombinant Genentech Cystic fibrosis... [Pg.695]

Pulmozyme (dornase-a, rDNase Genentech Cystic fibrosis 1993 (USA)... [Pg.507]

Retention of viscous purulent secretions, which contain high concentrations of extracellular DNA—released by degenerating leukocytes that accumulate in response to infection [24]—in the airways contributes both to reduced pulmonary function and to exacerbations of infection [24,25], Digestion of DNA polymers in purulent secretion with DNAse (dornase-a or Pulmozyme) has been shown to reduce sputum viscosity in cystic fibrosis patients. The availability of recombinant DNAse has allowed its use in an aerosol formulation to deliver the enzyme into the deep lung alveoli of CF patients. The purihed glycoprotein contains 260 amino acids with an approximate molecular weight of 37,000 daltons [26], The primary amino-acid sequence is identical to that of the... [Pg.253]

Dosage form Pulmozyme Inhalation Solution is a sterile, preservative-free, highly purihed solution of recombinant human deoxyribonuclease I (dornase alfa). Each Pulmozyme single-use ampule will deliver 2.5 ml of the solution to the nebulizer bowl. The aqueous solution contains domase alfa l.Omg/ml. [Pg.260]

Pharmacokinetics The pharmacokinetics of dornase alfa have not been characterized. Minimal systemic absorption occurs via inhalation. [Pg.260]

Aerosolized DNase (dornase) is a therapeutic protein designed for alveoli delivery to achieve local effects in the deep lung. Aerosolized DNase is formulated as a pulmonary dosage form, targeted for deep-lung delivery to reduce opportunistic infections due to the increased viscosity of mucus in the lung that affects respiratory function in patients with cystic fibrosis. [Pg.344]

DNAse, dornase alfa, human recombinant deosyribonucelase I (rhDNAse), produced in CHO cells... [Pg.452]

Dornase alfa [USAN BAN INN] Deoxyribonuclease (human clone 18-1 protein moiety) [CAS]... [Pg.506]

Shire, S. J. (1996), Stability, characterization and formulation of recombinant human deoxyribonuclease (Pulmozyme , Dornase Alpha), in Pearlman, R., and Wang, Y. J. Eds., Formulation, Characterization and Stability of Protein Drugs, Plenum Press, New York, pp. 393 126. [Pg.685]

Mucolytics Pulmozyme (Genentech) Dornase alfa (recombinant human deoxyribonuclease DNAse) In 2.5 mL ampoules Preservative-free. With 0.15mg/mL calcium chloride dihydrate and 8.77mg/mL sodium chloride... [Pg.234]

PULMOZYME (Dornase Genentech alfa) [(CHO-expressed recombinant glycoprotein-human deoxyribonuclease I (rhDNase)]... [Pg.326]

Pancreatic dornase - [EXPECTORANTS, ANTITUSSIVES AND RELATED AGENTS] (Vol 9)... [Pg.719]

E J. Accurso. Aerosolised domase alfa In cystic fibrosis patients with clinically mild tuns disease. Dornase Alia Clin, Ser. 2 1-6 (1995),... [Pg.304]

Dornase alpha Recombinant enzyme Pulmozyme (rhDNAse)... [Pg.455]

Dornase alfa is phosphorylated glycosylated recombinant human deoxyribonuclease. It is given daily by inhalation of a nebulised solution containing 2500 units (2.5 mg). It is of modest value only in patients with cystic fibrosis, whose genetic defect in chloride transport causes particularly viscous sputum. The blocked airways, as well as the sputum itself, are a trap for pathogens and the lysis of invading neutrophils leads to substantial levels of free and very viscous DNA within the CF airways. [Pg.551]

See other pages where Dornase is mentioned: [Pg.707]    [Pg.586]    [Pg.616]    [Pg.588]    [Pg.618]    [Pg.43]    [Pg.1641]    [Pg.139]    [Pg.623]    [Pg.259]    [Pg.260]    [Pg.533]    [Pg.555]    [Pg.119]    [Pg.139]    [Pg.383]    [Pg.707]    [Pg.707]    [Pg.114]    [Pg.954]    [Pg.689]    [Pg.268]   
See also in sourсe #XX -- [ Pg.23 ]

See also in sourсe #XX -- [ Pg.285 ]

See also in sourсe #XX -- [ Pg.285 ]



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Dornase alfa

Dornase alpha

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