Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Dornase alfa

Dornase alfa is produced by genetically engineered Chinese Hamster ovary cells containing DNA encoding for the native human protein deoxyribunuclease I. It is purified by tangential flow filtration and column chromatography. [Pg.707]

Dornase alfa (Pulmozyme ) is a recombinant human (rh) DNase that selectively cleaves extracellular deoxyribonucleic acid (DNA). This DNA is released during neutrophil degradation and contributes to the high viscosity of CF sputum. Nebulization of dornase alfa 2.5 mg once or twice daily improves daily pulmonary symptoms and function, reduces pulmonary exacerbations, and improves quality of life.16 N-acetylcysteine and hypertonic saline are other mucolytic agents that are occasionally used however, they are not preferred agents due to a greater incidence of bronchospasm and unpleasant odor and taste.5... [Pg.250]

Pulmozyme Dornase alfa, recombinant Genentech Cystic fibrosis... [Pg.695]

Dosage form Pulmozyme Inhalation Solution is a sterile, preservative-free, highly purihed solution of recombinant human deoxyribonuclease I (dornase alfa). Each Pulmozyme single-use ampule will deliver 2.5 ml of the solution to the nebulizer bowl. The aqueous solution contains domase alfa l.Omg/ml. [Pg.260]

Pharmacokinetics The pharmacokinetics of dornase alfa have not been characterized. Minimal systemic absorption occurs via inhalation. [Pg.260]

DNAse, dornase alfa, human recombinant deosyribonucelase I (rhDNAse), produced in CHO cells... [Pg.452]

Dornase alfa [USAN BAN INN] Deoxyribonuclease (human clone 18-1 protein moiety) [CAS]... [Pg.506]

Mucolytics Pulmozyme (Genentech) Dornase alfa (recombinant human deoxyribonuclease DNAse) In 2.5 mL ampoules Preservative-free. With 0.15mg/mL calcium chloride dihydrate and 8.77mg/mL sodium chloride... [Pg.234]

Dornase alfa is phosphorylated glycosylated recombinant human deoxyribonuclease. It is given daily by inhalation of a nebulised solution containing 2500 units (2.5 mg). It is of modest value only in patients with cystic fibrosis, whose genetic defect in chloride transport causes particularly viscous sputum. The blocked airways, as well as the sputum itself, are a trap for pathogens and the lysis of invading neutrophils leads to substantial levels of free and very viscous DNA within the CF airways. [Pg.551]

Dornase alfa Pulmozyme (Genentech) Respiratory complications of cystic fibrosis... [Pg.274]

Derelle J, Bertolo-Houriez E, Marchal F, Weber M, Virion JM, VidaUhet M. Evolution respiratoire de patients atteints de mucoviscidose traites par mucofluidifiants puis par dornase alfa. [Respiratory evolution of patient with mucoviscidosis treated with mucolytic agents plus dornase alfa.] Arch Pediatr 1998 5(4) 371-7. [Pg.1185]

Dornase alfa is human recombinant deoxyribonuclease. Daily therapy with dornase alfa in patients with cystic fibrosis can reduce the frequency of respiratory infections and improve lung function in patients with bronchiectasis. [Pg.1185]

The role of dornase alfa in modifying bronchial secretions in patients with cystic fibrosis has been evaluated in 54 subjects aged 5 years or over (1). They were treated for 12 months with mesna by nebulizer bd and oral ambroxol (30 mg bd). Dornase alfa was then given once daily by aerosol 2.5 mg for 12 months. Mesna and ambroxol caused reductions in FEVi nd FVC (FEVi feu by 11%, FVC by 13%). After 12 months of dornase aUa, FEVi had increased by 7.7% and FVC by 5.3%. The patients found treatment with dornase alfa more acceptable than mucoljdic therapy. Hemoptysis was the only reported adverse effect, but it occurred frequently in only one patient. [Pg.1185]

Pulmonary Liquid or powder formulations, nebulisers, metered dose inhalers, dry powder inhalers Pulmozyme (dornase alfa)... [Pg.454]

DNAse is a human endonuclease, normally present in saliva, urine, pancreatic secretions, and blood. The enzyme catalyzes the hydrolysis of extracellular DNA into oligonucleotides. Aerosoliz recombinant human DNAse (rhDNAse), dornase alfa. Pulmozyme, has been formulated into an inhalation agent for the treatment of pulmonary disease in patients with cy.stic fibrosis (CF). [Pg.185]

H. M. Bryson and E. M. Sorkin. Dornase alfa a review of its pharmacological properties and therapeutic potential in cystic fibrosis. Drugs 48 894-906 (1994). [Pg.301]

F. J. Accurso. Aerosolised dornase alfa in cystic fibrosis patients with clinically mild lung disease. Dornase Alfa Clin. Ser. 2 1-6 (1995). [Pg.304]

USA dornase alfa enzyme Pulmozyme AERx-dornase alfa Recombinant human deoxyribonuclease 1, human clone 18-1 expressed in CHO cells Cystic fibrosis... [Pg.479]

See other pages where Dornase alfa is mentioned: [Pg.707]    [Pg.586]    [Pg.616]    [Pg.588]    [Pg.618]    [Pg.1641]    [Pg.139]    [Pg.623]    [Pg.259]    [Pg.260]    [Pg.119]    [Pg.139]    [Pg.383]    [Pg.707]    [Pg.707]    [Pg.114]    [Pg.954]    [Pg.273]    [Pg.1185]    [Pg.194]    [Pg.649]    [Pg.674]    [Pg.331]    [Pg.1842]    [Pg.1852]   
See also in sourсe #XX -- [ Pg.250 ]

See also in sourсe #XX -- [ Pg.259 , Pg.260 ]

See also in sourсe #XX -- [ Pg.383 ]

See also in sourсe #XX -- [ Pg.178 ]



SEARCH



Dornase

© 2024 chempedia.info