Dog gastric mucosa

Structures of the glycosphingolipids characterized from hog and dog gastric mucosa. 

Examination of the neutral glycolipids in the aqueous fraction of a buffered tetrahydrofuran extract of dog gastric mucosa indicated presence of glycosphingolipids containing significant amounts of N-acetylgalactosamine, but only traces of fucose (26). 

A similar conclusion as to the content of fucolipids in dog gastric mucosa was reached earlier by McKibbin and Lyerly (31). 

Figure 1-34. Time course of alkalinization of the medium in which oxyntic cell microsomes were suspended following addition of ATP. The microsome membrane was inside out, so that acid was secreted into the interior and corresponding alkali accumulated in the exterior medium. Trace a in the presence of the ionophore val-inomycin. Trace b when the microsomes were dispersed by a detergent. Traces c and d corresponding oxperiments in the presence of oligomycin. (From Lee J, Simpson G, Scholes P. An ATPase from dog gastric mucosa Changes in outer pH in suspensions of membrane vesicles accompanying ATP hydrolysis. Biochem Biophys Res Commun 60 825-832, 1974.)...

Lee J, Simpson G, Scholes P. An ATPase from dog gastric mucosa Changes in outer pH in suspensions of membrane vesicles accompanying ATP hydrolysis. Biochem Biophys Res Commun 60 825-832, 1974. 

Forsell H, Helander HF, Sundell GW (1986) Structure and function of the dog gastric mucosa during and after a 1-year treatment with omeprazole. I. Macro- and microscopic findings. Scand J Gastroenterol Suppl 118 79-81... 

A chronic toxicity study for DOSS was performed using beagle dogs [72]. The dogs showed no toxic effects over a one-year period. Not even an effect on gastric mucosa was found (in contradiction to an earlier study [101] see also [102]). 

The toxicity of papaverine has been studied,36 as have its effects on energy processes in myocardial mitochondria,37 on the release and metabolism of dopamine,38 on contractile force and C-nucleotide levels in dog myocardium,39 on serum-induced spasms in cerebral arterioles,40 and on production of PGE2 by rabbit gastric mucosa,41 and the biological effects of drotaverine,42 N-benzoylpapaverinium chloride,43 and norlaudanosoline44 have been studied. A rapid method for the determination of papaverine in plasma by h.p.l.c. has been described.45... 

As previously discussed, food effects are an important parameter for enteric-coated systems, especially for drugs, that are sensitive to food. Pancreatic enzyme-containing products fail when they come in contact too early with lipids, proteins, and carbohydrates present in food. The clinical efficacy of pancreatic enzymes formulated as enteric-coated tablets was investigated in man and dog [44], The enteric materials examined were hydroxypropyl methylcellulose phthal-ate (HPMCP), cellulose acetate phthalate (CAP), and the methacrylic acid copolymer USP/NF Type C. In vivo behavior monitored by x-ray scintigraphy showed clear differences between the three coating formulations. HPMCP-coated products adhered to the gastric mucosa, whereas CAP and methacrylate copolymer... 

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